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Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel
Ruiz Julián, María (Institut d'Investigació Biomèdica Sant Pau)
Orozco, Jorge Luís (Institut d'Investigació Biomèdica Sant Pau)
Gironell, Alexandre (Institut d'Investigació Biomèdica Sant Pau)

Date: 2018
Abstract: Primary orthostatic tremor (POT) is an infrequent disorder whose physiopathology is unknown. Current medication is largely ineffective or only offers mild benefits. A 75-year-old female with refractory POT treated with 4 mg/day of perampanel achieved complete symptom resolution. Owing to adverse effects, the patient reduced intake to 2 mg/day, but even at this lower dose the benefit was maintained. We report the complete resolution of POT symptoms using low doses of perampanel, an antiepileptic drug that blocks glutamate-mediated post-synaptic excitation. Further controlled studies are necessary to confirm this finding.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Primary orthostatic tremor ; Perampanel
Published in: Tremor and Other Hyperkinetic Movements, Vol. 8 (april 2018) , ISSN 2160-8288

PMID: 29686940
DOI: 10.7916/D8QZ3SZD

3 p, 604.1 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2018-06-18, last modified 2019-01-15

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