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Differences in Glycemic Control in Diabetic and Non-diabetic Patients with Parenteral Nutrition Using a Basal plus Correction Insulin Regimen : An Observational, Retrospective Study
Ramos, Analía (Institut d'Investigació Biomèdica Sant Pau)
Rabasa, Fernanda (Institut d'Investigació Biomèdica Sant Pau)
Mendoza, Lilian (Institut d'Investigació Biomèdica Sant Pau)
Cardenete, Joana (Institut d'Investigació Biomèdica Sant Pau)
Gill, Pedro (Institut d'Investigació Biomèdica Sant Pau)
Morilla, Alba (Institut d'Investigació Biomèdica Sant Pau)
Cardona, Daniel (Institut d'Investigació Biomèdica Sant Pau)
Pérez Pérez, Antonio (Universitat Autònoma de Barcelona. Departament de Medicina)
Universitat Autònoma de Barcelona

Date: 2018
Abstract: Hyperglycemia is a frequent complication of parenteral nutrition (PN) in patients both with and without diabetes mellitis (DM). The aim of this study was to evaluate the quality of glucose control achieved with basal plus-correction insulin in surgical patients with and without a history of DM receiving PN. Retrospective evaluation of a protocol applied during the period of January 2013-December 2015. The insulin dose was started at 0. 4 and 0. 3 IU/kg/day in patients with previous DM and without a history of DM, respectively, and the target blood glucose (BG) was < 180 mg/dl. Mean BG levels, insulin total daily dose (TDD) and hypoglycemic (< 70 mg/dl) events on different days of PN were also evaluated. Forty-one patients with previous type 2 DM and 39 without DM were evaluated. Glycemic control in both groups was as follows: during the first 48 h (230. 4 ± 67 vs. 189. 4 ± 38 mg/dl, p = 0. 002); at the midpoint (224. 6 ± 58 vs. 181. 3 ± 27 mg/dl, p = 0. 003); 48 h before ending TPN (196. 4 ± 43 vs. 169. 8 ± 40 mg/dl, p = 0. 004). Insulin TDD was 0. 5 ± 0. 3 U/kg/day in patients with DM and 0. 37 ± 0. 3 units/kg/day in those without DM (p < 0. 05). A total of 18 patients experienced hypoglycemic events, without differences between the groups. A basal-correction insulin regimen is an alternative method for managing hyperglycemia in non-critically ill surgical patients on PN.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; article de revisió ; publishedVersion
Subject: Diabetic patients ; Hyperglycemia ; Non-diabetic patients ; Parenteral nutrition
Published in: Diabetes Therapy, Vol. 9 (may 2018) , p. 1359-1367, ISSN 1869-6961

DOI: 10.1007/s13300-018-0433-1
PMID: 29725969

9 p, 532.7 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Published articles

 Record created 2018-06-18, last modified 2020-11-07

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