A longitudinal study of brain anatomy changes preceding dementia in Down syndrome
Pujol Nuez, Jesús (Hospital del Mar (Barcelona, Catalunya))
Fenoll, Raquel (Hospital del Mar (Barcelona, Catalunya))
Ribas-Vidal, Núria (Institut Assistència Sanitària, Parc Hospitalari Martí i Julià (Girona))
Martínez Vilavella, Gerard (Hospital del Mar (Barcelona, Catalunya))
Blanco Hinojo, Laura (Centro de Investigación Biomédica en Red de Salud Mental)
García Alba, Javier (Hospital Universitario de la Princesa (Madrid))
Deus Yela, Juan (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Novell, Ramon (Institut Assistència Sanitària, Parc Hospitalari Martí i Julià (Girona))
Esteba Castillo, Susanna (Institut Assistència Sanitària, Parc Hospitalari Martí i Julià (Girona))

Data:	2018
Resum:	We longitudinally assessed Down syndrome individuals at the age of risk of developing dementia to measure changes in brain anatomy and their relationship to cognitive impairment progression. Forty-two Down syndrome individuals were initially included, of whom 27 (mean age 46. 8 years) were evaluable on the basis of completing the 2-year follow-up and success in obtaining good quality MRI exams. Voxel-based morphometry was used to estimate regional brain volumes at baseline and follow-up on 3D anatomical images. Longitudinal volume changes for the group and their relationship with change in general cognitive status and specific cognitive domains were mapped. As a group, significant volume reduction was identified in the substantia innominata region of the basal forebrain, hippocampus, lateral temporal cortex and left arcuate fasciculus. Volume reduction in the substantia innominata and hippocampus was more prominent in individuals whose clinical status changed from cognitively stable to mild cognitive impairment or dementia during the follow-up. Relevantly, longitudinal memory score change was specifically associated with volume change in the hippocampus, prospective memory with prefrontal lobe and verbal comprehension with language-related brain areas. Results are notably concordant with the well-established anatomical changes signaling the progression to dementia in Alzheimer's disease, despite the dense baseline pathology that developmentally accumulates in Down syndrome. This commonality supports the potential value of Down syndrome as a genetic model of Alzheimer's neurodegeneration and may serve to further support the view that Down syndrome patients are best candidates to benefit from treatment research in Alzheimer's disease.
Ajuts:	Instituto de Salud Carlos III PI12/02019 Instituto de Salud Carlos III PSI-2014-53524-P
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Brain aging ; Alzheimer's ; Cognitive aging
Publicat a:	NeuroImage, Vol. 18 (january 2018) , p. 160-166, ISSN 2213-1582

DOI: 10.1016/j.nicl.2018.01.024
PMID: 29868444

7 p, 553.1 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats