The circadian clock sets the time of DNA replication licensing to regulate growth in Arabidopsis
Fung Uceda, Jorge Alberto (Centre de Recerca en Agrigenòmica)
Lee, Kyounghee (Sungkyunkwan University. Department of Biological Sciences)
Seo, Pil Joon (Sungkyunkwan University. Department of Biological Sciences)
Polyn, Stefanie (Universiteit Gent. Department of Plant Biotechnology and Bioinformatics)
De Veylder, Lieven (Universiteit Gent. Department of Plant Biotechnology and Bioinformatics)
Mas, Paloma (Centre de Recerca en Agrigenòmica)

Date:	2018
Abstract:	The circadian clock and cell cycle as separate pathways have been well documented in plants. Elucidating whether these two oscillators are connected is critical for understanding plant growth. We found that a slow-running circadian clock decelerates the cell cycle and, conversely, a fast clock speeds it up. The clock component TOC1 safeguards the G1-to-S transition and controls the timing of the mitotic cycle at early stages of leaf development. TOC1 also regulates somatic ploidy at later stages of leaf development and in hypocotyl cells. The S-phase is shorter and delayed in TOC1 overexpressing plants, which correlates with the diurnal repression of the DNA replication licensing gene CDC6 through binding of TOC1 to the CDC6 promoter. The slow cell-cycle pace in TOC1-ox also results in delayed tumor progression in inflorescence stalks. Thus, TOC1 sets the time of the DNA pre-replicative machinery to control plant growth in resonance with the environment.
Grants:	European Commission 607880 Ministerio de Economía y Competitividad BFU2016-77236-P Ministerio de Economía y Competitividad SEV-2015-0533 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1211
Rights:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Circadian clock ; Cell cycle ; S-phase ; DNA replication licensing ; Endocycle ; Plant growth ; Tumor progression ; Arabidopsis thaliana
Published in:	Developmental Cell, Vol. 45, issue 1 (April 2018) , p. 101-113, ISSN 1534-5807

DOI: 10.1016/j.devcel.2018.02.022

Post-print 47 p, 1.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > CRAG (Centre for Research in Agricultural Genomics)
Articles > Research articles
Articles > Published articles