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Página principal > Artículos > Artículos publicados > Noninvasive Assessment of an Engineered Bioactive Graft in Myocardial Infarction: Impact on Cardiac Function and Scar Healing |
Fecha: | 2017 |
Resumen: | Cardiac tissue engineering, which combines cells and biomaterials, is promising for limiting the sequelae of myocardial infarction (MI). We assessed myocardial function and scar evolution after implanting an engineered bioactive impedance graft (EBIG) in a swine MI model. The EBIG comprises a scaffold of decellularized human pericardium, green fluorescent protein-labeled porcine adipose tissue-derived progenitor cells (pATPCs), and a customized-design electrical impedance spectroscopy (EIS) monitoring system. Cardiac function was evaluated noninvasively by using magnetic resonance imaging (MRI). Scar healing was evaluated by using the EIS system within the implanted graft. Additionally, infarct size, fibrosis, and inflammation were explored by histopathology. Upon sacrifice 1 month after the intervention, MRI detected a significant improvement in left ventricular ejection fraction (7. 5%64. 9% vs. 1. 4%63. 7%; p = . 038) and stroke volume (11. 565. 9 ml vs. 364. 5 ml; p = . 019) in EBIG-treated animals. Noninvasive EIS data analysis showed differences in both impedance magnitude ratio (20. 02 6 0. 04 per day vs. 20. 48 6 0. 07 per day; p = . 002) and phase angle slope (20. 18°60. 24° per day vs. 23. 52°60. 84° per day; p = . 004) in EBIG compared with control animals. Moreover, in EBIG-treated animals, the infarct size was 48% smaller (3. 4%60. 6% vs. 6. 5%61%; p = . 015), less inflammation was found by means of CD25+ lymphocytes (0. 65 6 0. 12 vs. 1. 26 6 0. 2; p = . 006), and a lower collagen I/III ratio was detected (0. 4960. 06 vs. 1. 6660. 5; p = . 019). An EBIG composed of acellular pericardium refilled with pATPCs significantly reduced infarct size and improved cardiac function in a preclinical model of MI. Noninvasive EIS monitoring was useful for tracking differential scar healing in EBIG-treated animals, which was confirmed by less inflammation and altered collagen deposit. |
Ayudas: | Ministerio de Economía y Competitividad SAF2011-30067 Ministerio de Economía y Competitividad SAF2014-59892 Agència de Gestió d'Ajuts Universitaris i de Recerca SGR-2014 Instituto de Salud Carlos III FIS/PI14/01682 |
Nota: | Altres Ajuts: Fundació La MARATÓ de TV3 Grants 201516 and 201502; Fundació Daniel Bravo Andreu; Sociedad Española de Cardiología; Societat Catalana de Cardiologia; Generalitat de Catalunya Grant SGR 2014; and Acadèmia de Ciències Mèdiques i de la Salut de Catalunya i de Balears. Red de Terapia Celular Project RD12/0019/0029, Red de Investigación Cardiovascular Project RD12/0042/0047, (...) and cofounded by ISCIII-Sudirección General de Evaluación y el Fondo Europeo de Desarrollo Regional. |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Myocardial infarction ; Magnetic resonance imaging ; Bioimpedance ; Angiogenesis ; Progenitor cells |
Publicado en: | Stem cells translational medicine, Vol. 6 (2017) , p. 647-655 |
9 p, 3.9 MB |