Apoptosis, Toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens
Martínez, Isidoro (Centro Nacional de Microbiología (Espanya))
Oliveros, Juan C. (Centro Nacional de Biotecnologia)
Cuesta, Isabel (Centro Nacional de Microbiología (Espanya))
de la Barrera, Jorge (Centro Nacional de Microbiología (Espanya))
Ausina, Vicente (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Casals, Cristina (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular)
de Lorenzo, Alba (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular)
García, Ernesto (Centro de Investigaciones Biológicas (Madrid))
García Fojeda, Belén (Universidad Complutense de Madrid. Departamento de Bioquímica y Biología Molecular)
Garmendia, Junkal (Universidad Pública de Navarra. Instituto de Agrobiotecnología)
González Nicolau, Mar (Fundación de Investigación Sanitaria de las Islas Baleares)
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Menéndez, Margarita (Instituto de Química Física "Rocasolano")
Moranta, D. (Fundación de Investigación Sanitaria de las Islas Baleares)
Nieto, Amelia (Centro Nacional de Biotecnologia)
Ortín, Juan (Centro Nacional de Biotecnologia)
Pérez González, Alicia (Centro Nacional de Biotecnologia)
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ramos Sevillano, Elisa (Centro de Investigaciones Biológicas (Madrid))
Regueiro, Verónica (Fundación de Investigación Sanitaria de las Islas Baleares)
Rodriguez Frandsen, Ariel (Centro Nacional de Biotecnologia)
Solís, Dolores (Instituto de Química Física "Rocasolano")
Yuste, José (Centro de Investigaciones Biológicas (Madrid))
Bengoechea, José A. (Fundación de Investigación Sanitaria de las Islas Baleares)
Melero, José A. (Centro Nacional de Microbiología (Espanya))
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.
Grants:	Instituto de Salud Carlos III PI15CIII/00024 Ministerio de Economía y Competitividad SAF2015-67033-R Ministerio de Economía y Competitividad BFU2014-57797-R Ministerio de Economía y Competitividad SAF2015-65307-R Ministerio de Economía y Competitividad SAF2012-39444-C01/02 Ministerio de Economía y Competitividad SAF2012-39841 Ministerio de Economía y Competitividad SAF2015-66520-R Ministerio de Economía y Competitividad BFU2015-70052-R European Commission PITN-GA-2012-317297 Ministerio de Economía y Competitividad BES-2013-065355
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Respiratory pathogens ; Host response ; Core of up-regulated genes ; Bacterial infections ; Viral infections
Published in:	Frontiers in microbiology, Vol. 8 (2017) , p. 1-13, ISSN 1664-302X

DOI: 10.3389/fmicb.2017.00276
PMID: 28298903

13 p, 2.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles