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Pattern of Regional Cortical Thinning Associated with Cognitive Deterioration in Parkinson's Disease
Pagonabarraga Mora, Javier (Universitat Autònoma de Barcelona. Departament de Medicina)
Corcuera Solano, Idoia (Institut d'Investigació Biomèdica Sant Pau)
Vives Gilabert, Yolanda (Institut de Física d'Altes Energies)
Llebaria, Gisela (Centro de Investigación Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED))
García-Sánchez, Carmen (Universitat Autònoma de Barcelona. Departament de Medicina)
Pascual Sedano, Berta (Institut d'Investigació Biomèdica Sant Pau)
Delfino Reznicek, Manuel Carlos (Universitat Autònoma de Barcelona. Departament de Física)
Kulisevsky, Jaime (Universitat Autònoma de Barcelona. Departament de Medicina)
Gómez Ansón, Beatriz (Institut d'Investigació Biomèdica Sant Pau)

Date: 2013
Abstract: Background: Dementia is a frequent and devastating complication in Parkinson's disease (PD). There is an intensive search for biomarkers that may predict the progression from normal cognition (PD-NC) to dementia (PDD) in PD. Mild cognitive impairment in PD (PD-MCI) seems to represent a transitional state between PD-NC and PDD. Few studies have explored the structural changes that differentiate PD-NC from PD-MCI and PDD patients. Objectives and Methods: We aimed to analyze changes in cortical thickness on 3. 0T Magnetic Resonance Imaging (MRI) across stages of cognitive decline in a prospective sample of PD-NC (n = 26), PD-MCI (n = 26) and PDD (n = 20) patients, compared to a group of healthy subjects (HC) (n = 18). Cortical thickness measurements were made using the automatic software Freesurfer. Results: In a sample of 72 PD patients, a pattern of linear and progressive cortical thinning was observed between cognitive groups in cortical areas functionally specialized in declarative memory (entorhinal cortex, anterior temporal pole), semantic knowledge (parahippocampus, fusiform gyrus), and visuoperceptive integration (banks of the superior temporal sulcus, lingual gyrus, cuneus and precuneus). Positive correlation was observed between confrontation naming and thinning in the fusiform gyrus, parahippocampal gyrus and anterior temporal pole; clock copy with thinning of the precuneus, parahippocampal and lingual gyrus; and delayed memory with thinning of the bilateral anteromedial temporal cortex. Conclusions: The pattern of regional decreased cortical thickness that relates to cognitive deterioration is present in PD-MCI patients, involving areas that play a central role in the storage of prior experiences, integration of external perceptions, and semantic processing.
Note: Altres ajuts: Sociedad Española de Radiologia Médica (SERAM 06–09)
Note: Número d'acord de subvenció ISCIII/FIS/PI10/01498
Note: Número d'acord de subvenció ISCIII/FIS/PI07/770
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: PLoS ONE, Vol. 8 Núm. 1 (30 2013) , p. e54980, ISSN 1932-6203

DOI: 10.1371/journal.pone.0054980
PMID: 23359616


8 p, 233.4 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2019-01-15, last modified 2019-06-24



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