Pattern of Regional Cortical Thinning Associated with Cognitive Deterioration in Parkinson's Disease
Pagonabarraga Mora, Javier (Universitat Autònoma de Barcelona. Departament de Medicina)
Corcuera Solano, Idoia (Institut d'Investigació Biomèdica Sant Pau)
Vives-Gilabert, Yolanda (Institut de Física d'Altes Energies)
Llebaria, Gisela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
García Sánchez, Carmen (Universitat Autònoma de Barcelona. Departament de Medicina)
Pascual-Sedano, Berta María (Institut d'Investigació Biomèdica Sant Pau)
Delfino, Manuel (Universitat Autònoma de Barcelona. Departament de Física)
Kulisevsky, Jaime (Universitat Autònoma de Barcelona. Departament de Medicina)
Gómez-Ansón, Beatriz (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2013
Abstract:	Background: Dementia is a frequent and devastating complication in Parkinson's disease (PD). There is an intensive search for biomarkers that may predict the progression from normal cognition (PD-NC) to dementia (PDD) in PD. Mild cognitive impairment in PD (PD-MCI) seems to represent a transitional state between PD-NC and PDD. Few studies have explored the structural changes that differentiate PD-NC from PD-MCI and PDD patients. Objectives and Methods: We aimed to analyze changes in cortical thickness on 3. 0T Magnetic Resonance Imaging (MRI) across stages of cognitive decline in a prospective sample of PD-NC (n = 26), PD-MCI (n = 26) and PDD (n = 20) patients, compared to a group of healthy subjects (HC) (n = 18). Cortical thickness measurements were made using the automatic software Freesurfer. Results: In a sample of 72 PD patients, a pattern of linear and progressive cortical thinning was observed between cognitive groups in cortical areas functionally specialized in declarative memory (entorhinal cortex, anterior temporal pole), semantic knowledge (parahippocampus, fusiform gyrus), and visuoperceptive integration (banks of the superior temporal sulcus, lingual gyrus, cuneus and precuneus). Positive correlation was observed between confrontation naming and thinning in the fusiform gyrus, parahippocampal gyrus and anterior temporal pole; clock copy with thinning of the precuneus, parahippocampal and lingual gyrus; and delayed memory with thinning of the bilateral anteromedial temporal cortex. Conclusions: The pattern of regional decreased cortical thickness that relates to cognitive deterioration is present in PD-MCI patients, involving areas that play a central role in the storage of prior experiences, integration of external perceptions, and semantic processing.
Grants:	Instituto de Salud Carlos III FIS/PI10/01498 Instituto de Salud Carlos III FIS/PI07/770
Note:	Altres ajuts: Sociedad Española de Radiologia Médica (SERAM 06-09)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 8 Núm. 1 (30 2013) , p. e54980, ISSN 1932-6203

DOI: 10.1371/journal.pone.0054980
PMID: 23359616

8 p, 233.4 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Institut de Física d’Altes Energies (IFAE)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles