Web of Science: 6 citations, Scopus: 6 citations, Google Scholar: citations,
Protection of Spanish Ibex (Capra pyrenaica) against Bluetongue Virus Serotypes 1 and 8 in a Subclinical Experimental Infection
Lorca Oró, Cristina (Fundació Centre de Recerca en Sanitat Animal)
Pujols, Joan (Fundació Centre de Recerca en Sanitat Animal)
García-Bocanegra, Ignacio (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Mentaberre, Gregorio (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
Granados, José Enrique (Espacio Natural Sierra Nevada)
Solanes Foz, David (Fundació Centre de Recerca en Sanitat Animal)
Fandos, Paulino (Parque Natural Sierras de Cazorla, Segura y Las Villas)
Galindo Cardiel, Iván (Fundació Centre de Recerca en Sanitat Animal)
Domingo, Mariano (Universitat Autònoma de Barcelona. Departament de Patologia i Producció Animals)
Lavín González, Santiago (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)
López-Olvera, Jorge Ramón (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge)

Date: 2012
Abstract: Many wild ruminants such as Spanish ibex (Capra pyrenaica) are susceptible to Bluetongue virus (BTV) infection, which causes disease mainly in domestic sheep and cattle. Outbreaks involving either BTV serotypes 1 (BTV-1) and 8 (BTV-8) are currently challenging Europe. Inclusion of wildlife vaccination among BTV control measures should be considered in certain species. In the present study, four out of fifteen seronegative Spanish ibexes were immunized with a single dose of inactivated vaccine against BTV-1, four against BTV-8 and seven ibexes were non vaccinated controls. Seven ibexes (four vaccinated and three controls) were inoculated with each BTV serotype. Antibody and IFN-gamma responses were evaluated until 28 days after inoculation (dpi). The vaccinated ibexes showed significant (P,0. 05) neutralizing antibody levels after vaccination compared to non vaccinated ibexes. The non vaccinated ibexes remained seronegative until challenge and showed neutralizing antibodies from 7 dpi. BTV RNA was detected in the blood of non vaccinated ibexes from 2 to the end of the study (28 dpi) and in target tissue samples obtained at necropsy (8 and 28 dpi). BTV-1 was successfully isolated on cell culture from blood and target tissues of non vaccinated ibexes. Clinical signs were unapparent and no gross lesions were found at necropsy. Our results show for the first time that Spanish ibex is susceptible and asymptomatic to BTV infection and also that a single dose of vaccine prevents viraemia against BTV-1 and BTV-8 replication.
Note: Número d'acord de subvenció FAU2008-00019-C03-01, Instituto Nacional de Investigación y Tecnología Agroalimentaria (INIA).
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Català.
Document: article ; recerca ; publishedVersion
Subject: Veterinària ; Llengua blava ; Ovelles ; Virosi
Published in: Plos One, Vol. 7 Núm. 5 (2012)

DOI: 10.1371/journal.pone.0036380
PMID: 22666321


9 p, 1.3 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2019-02-28, last modified 2019-09-05



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