Web of Science: 4 cites, Scopus: 3 cites, Google Scholar: cites,
Fixation of light weight polypropylene mesh with n-butyl-2-cyanocrylate in pelvic floor surgery : Experimental design approach in sheep for effectiveness evaluation
Barbosa, Sandra (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Nieves, Tania (B. Braun Surgical S.A.)
García Arnas, Félix (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Cepeda, Eva (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Moll Sánchez, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirugia Animals)
Marco Valle, Alberto (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Weis, Christine (B. Braun Surgical S.A.)
Turon, Pau (B. Braun Surgical S.A.)
Vergara, Patri (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Data: 2015
Resum: Objective. The aim of this study was to find a proper experimental design and to evaluate n-butyl-2-cyanoacrylate (Histoacryl) as a fixation method for a light-weight and large pore PP mesh (Synthetic PP Mesh-1) using the sheep as an animal model. Methods. Posterior vaginal implantation by means of episiotomy was used to implant 8 ewes which were evaluated macroscopically and histologically at 3 months (n = 4) and 6 months (n = 4) post-surgery. In previous pilot studies anterior vaginal implantation was evaluated, as well as different synthetic mesh materials, sizes and fixation methods (n = 1 to 3) during three weeks. In all cases a clinical evaluation of the animal was performed. Results. A reduction in the mesh size (Synthetic PP Mesh-1) together with precise application of the surgical glue Histoacryl to fix the mesh yielded significantly better histocompatibility results (P < 0. 01) compared to larger size or other fixation methods. Conclusion. The combination of Synthetic PP Mesh-1 with Histoacryl offered a high degree of graft integration without vaginal ulceration and a minimal foreign body reaction, being the sheep a proper animal model to test these types of medical devices.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Animals ; Enbucrilate ; Episiotomy ; Female ; Humans ; Models, Animal ; Pelvic Floor ; Sheep ; Surgical Mesh ; Vagina
Publicat a: BioMed Research International, Vol. 2015 (2015) , art. 737683, ISSN 2314-6141

DOI: 10.1155/2015/737683
PMID: 26221605


10 p, 3.9 MB

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