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Heart–lung–muscle anti-SAE syndrome : an atypical severe combination
Zamora Serrallonga, Elisabet (Universitat Autònoma de Barcelona. Departament de Medicina)
Seder Colomina, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol. Servei de Cardiologia)
Holgado Pérez, Susana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol. Servei de Reumatologia)
Quirant Sanchez, Bibiana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol. Servei d'Immunologia)
Mate Sanz, José Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol. Servei de Patologia)
Martínez Cáceres, Eva M. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Casafont Solé, Ivette (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol. Servei de Reumatologia)
Bayés Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol. Servei de Cardiologia)

Date: 2019
Abstract: A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart–lung–muscle involvement combined with anti-SAE antibodies was a severe combination.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Myocarditis ; Idiopathic inflammatory myopathy ; Anti-SAE antibody
Published in: Journal of clinical medicine, Vol. 8, issue 1 (Jan. 2019) , art. 20, ISSN 2077-0383

PMID: 30583602
DOI: 10.3390/jcm8010020


6 p, 1.9 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles

 Record created 2019-05-06, last modified 2019-05-31



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