Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
Ezpeleta, Lourdes (Universitat Autònoma de Barcelona. Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament)
Penelo Werner, Eva (Universitat Autònoma de Barcelona. Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament)
Osa, Nuria de la (Universitat Autònoma de Barcelona. Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament)
Navarro, José-Blas (Universitat Autònoma de Barcelona. Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament)
Fañanás Saura, Lourdes (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)
Fatjó-Vilas, Mar (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)

Date:	2019
Abstract:	The objective was to obtain developmental trajectories combining callous-unemotional traits and the number of stressful life-events between ages 3 and 9 years and to ascertain their association with the polymorphism rs53576 at the Oxytocin Receptor gene (OXTR). A total of 377 children were assessed yearly from ages 3 to 9 years. Latent class growth analysis for parallel processes was used to identify distinct trajectories for callous-unemotional traits (assessed using the Inventory of Callous-Unemotional Traits, ICU) and number of stressful life-events, and then the influence of being an A allele carrier on class membership was included with OXTR genotypes as a binary time-invariant predictor, following a 3-step approach. A 3-class model showed the highest entropy (. 859) and adequate posterior probabilities of class membership (≥. 884). Class 1 (n = 226, 59. 9%) included children with low and stable ICU scores and low and descending stressful life-events; class 2 (n = 127, 33. 7%) included children with high and ascending ICU scores and low and slightly descending stressful life-events; and class 3 (n = 24, 6. 4%) included children with persistently high profiles both for ICU scores and stressful life-events. Carrying an A allele (genotypes GA/AA) increased the odds of pertaining to class 3 (high and persistent ICU scores and stressful life-events) as opposed to class 2 (OR = 4. 27, p = 0. 034) or class 1 (OR = 3. 81, p = 0. 042). The results suggest the importance of considering callous-unemotional traits and stressful life-events in conjunction. In addition, the genetic variability of OXTR (rs53576) may help to understand individual differences in early development.
Grants:	Ministerio de Economía y Competitividad PSI2015-63965-R Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-312
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Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Callous-unemotional ; Developmental trajectories ; Life events ; OXTR ; Rs53576
Published in:	Journal of abnormal child psychology, 2019 , ISSN 0091-0627

DOI: 10.1007/s10802-019-00548-z
PMID: 31030321

Post-print 39 p, 388.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Research group Epidemiology and Diagnosis in Psychopathology of Development (UED)
Articles > Research articles
Articles > Published articles