Google Scholar: cites
Association of OXTR rs53576 with the developmental trajectories of callous-unemotional traits and life events in 3- to 9-year-old community children
Ezpeleta, L. (Universitat Autònoma de Barcelona. Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament)
Penelo Werner, Eva (Universitat Autònoma de Barcelona. Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament)
Osa, Nuria de la (Universitat Autònoma de Barcelona. Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament)
Navarro, J. B. (Universitat Autònoma de Barcelona. Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament)
Fañanás Saura, Lourdes (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)
Fatjó-Vilas, Mar (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)

Data: 2019
Resum: The objective was to obtain developmental trajectories combining callous-unemotional traits and the number of stressful life-events between ages 3 and 9 years and to ascertain their association with the polymorphism rs53576 at the Oxytocin Receptor gene (OXTR). A total of 377 children were assessed yearly from ages 3 to 9 years. Latent class growth analysis for parallel processes was used to identify distinct trajectories for callous-unemotional traits (assessed using the Inventory of Callous-Unemotional Traits, ICU) and number of stressful life-events, and then the influence of being an A allele carrier on class membership was included with OXTR genotypes as a binary time-invariant predictor, following a 3-step approach. A 3-class model showed the highest entropy (. 859) and adequate posterior probabilities of class membership (≥. 884). Class 1 (n = 226, 59. 9%) included children with low and stable ICU scores and low and descending stressful life-events; class 2 (n = 127, 33. 7%) included children with high and ascending ICU scores and low and slightly descending stressful life-events; and class 3 (n = 24, 6. 4%) included children with persistently high profiles both for ICU scores and stressful life-events. Carrying an A allele (genotypes GA/AA) increased the odds of pertaining to class 3 (high and persistent ICU scores and stressful life-events) as opposed to class 2 (OR = 4. 27, p = 0. 034) or class 1 (OR = 3. 81, p = 0. 042). The results suggest the importance of considering callous-unemotional traits and stressful life-events in conjunction. In addition, the genetic variability of OXTR (rs53576) may help to understand individual differences in early development.
Nota: Número d'acord de subvenció MINECO/PSI2015-63965-R
Nota: Número d'acord de subvenció AGAUR/2014/SGR312
Drets: Tots els drets reservats.
Llengua: Anglès.
Document: article ; recerca ; acceptedVersion
Matèria: Callous-unemotional ; Developmental trajectories ; Life events ; OXTR ; Rs53576
Publicat a: Journal of abnormal child psychology, 2019 , ISSN 0091-0627

DOI: 10.1007/s10802-019-00548-z


Disponible a partir de: 2020-05-01
Post-print
38 p, 246.4 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Grup de Recerca Epidemiologia i Diagnòstic en Psicopatologia del Desenvolupament (UED)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2019-05-06, darrera modificació el 2019-05-18



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