Characterization of nanoparticle batch-to-batch variability
Mülhopt, Sonja (Karlsruhe Institute of Technology. Institute for Technical Chemistry (Germany))
Diabaté, Silvia (Karlsruhe Institute of Technology. Institute for Toxicology and Genetics (Germany))
Dilger, Marco (Karlsruhe Institute of Technology. Institute for Toxicology and Genetics (Germany))
Adelhelm, Christel (Karlsruhe Institute of Technology. Institute for Applied Materials (Germany))
Anderlohr, Christopher (Karlsruhe Institute of Technology. Institute for Technical Thermodynamics and Refrigeration (Germany))
Bergfeldt, Thomas (Karlsruhe Institute of Technology. Institute for Applied Materials (Germany))
Gómez de la Torre, Johan (Uppsala University. Department of Engineering Sciences (Sweden))
Jiang, Yunhong (University of Bath. Department of Architecture and Civil Engineering (UK))
Valsami-Jones, Eugenia (University of Birmingham. School of Geography, Earth and Environmental Sciences (UK))
Langevin, Dominique (Université Paris Saclay. Laboratoire de Physique des Solides (France))
Lynch, Iseult (University of Birmingham. School of Geography, Earth and Environmental Sciences (UK))
Mahon, Eugene (University College Dublin. Centre for BioNano Interactions (Ireland))
Nelissen, Inge (Flemish Institute for Technological Research. Health Department (Belgium))
Piella, Jordi (Institut Català de Nanociència i Nanotecnologia)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Ray, Sikha (Karlsruhe Institute of Technology. Science and Technology of Nanosystems (Germany))
Schneider, Reinhard (Karlsruhe Institute of Technology. Laboratory for Electron Microscopy (Germany))
Wilkins, Terry (University of Leeds. School of Chemical and Process Engineering (UK))
Weiss, Carsten (Karlsruhe Institute of Technology. Institute for Toxicology and Genetics (Germany))
Paur, Hanns-Rudolf (Karlsruhe Institute of Technology. Institute for Technical Chemistry (Germany))

Data:	2018
Resum:	A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced.
Ajuts:	European Commission 262163
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Nanosafety ; Particle size ; Impurities ; Reactive oxygen species
Publicat a:	Nanomaterials, Vol. 8, Issue 5 (May 2018) , art. 311, ISSN 2079-4991

DOI: 10.3390/nano8050311
PMID: 29738461

24 p, 7.8 MB

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