Web of Science: 5 citations, Scopus: 5 citations, Google Scholar: citations,
Intrinsic and extrinsic properties affecting innate immune responses to nanoparticles : The case of cerium oxide
Casals Mercadal, Eudald (Vall d'Hebron Institut de Recerca)
Gusta, Muriel F. (Vall d'Hebron Institut de Recerca)
Piella, Jordi (Institut Català de Nanociència i Nanotecnologia)
Casals, Gregori (Hospital Clínic Universitari)
Jiménez Povedano, Wladimiro (Universitat de Barcelona. Departament de Biomedicina)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)

Date: 2017
Abstract: We review the apparent discrepancies between studies that report anti-inflammatory effects of cerium oxide nanoparticles (CeO NPs) through their reactive oxygen specieschelating properties and immunological studies highlighting their toxicity. We observe that several underappreciated parameters, such as aggregation size and degree of impurity, are critical determinants that need to be carefully addressed to better understand the NP biological effects in order to unleash their potential clinical benefits. This is because NPs can evolve toward different states, depending on the environment where they have been dispersed and how they have been dispersed. As a consequence, final characteristics of NPs can be very different from what was initially designed and produced in the laboratory. Thus, aggregation, corrosion, and interaction with extracellular matrix proteins critically modify NP features and fate. These modifications depend to a large extent on the characteristics of the biological media in which the NPs are dispersed. As a consequence, when reviewing the scientific literature, it seems that the aggregation state of NPs, which depends on the characteristics of the dispersing media, may be more significant than the composition or original size of the NPs. In this work, we focus on CeO NPs, which are reported sometimes to be protective and anti-inflammatory, and sometimes toxic and pro-inflammatory.
Note: Número d'acord de subvenció ISCIII/PI15/00777
Note: Número d'acord de subvenció MINECO/SAF2015-6412-R
Note: Número d'acord de subvenció EC/FP7/604602
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Nanoparticles ; Cerium oxide
Published in: Frontiers in immunology, Vol. 8 (August 2017) , art. 970, ISSN 1664-3224

Corrigendum: https://ddd.uab.cat/record/204860
DOI: 10.3389/fimmu.2017.00970
PMID: 28855907

7 p, 765.9 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2019-06-03, last modified 2019-07-05

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