Intrinsic and extrinsic properties affecting innate immune responses to nanoparticles : The case of cerium oxide
Casals, Eudald (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gusta, Muriel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Piella, Jordi (Institut Català de Nanociència i Nanotecnologia)
Casals, Gregori (Hospital Clínic Universitari)
Jiménez Povedano, Wladimiro (Universitat de Barcelona. Departament de Biomedicina)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)

Fecha:	2017
Resumen:	We review the apparent discrepancies between studies that report anti-inflammatory effects of cerium oxide nanoparticles (CeO NPs) through their reactive oxygen specieschelating properties and immunological studies highlighting their toxicity. We observe that several underappreciated parameters, such as aggregation size and degree of impurity, are critical determinants that need to be carefully addressed to better understand the NP biological effects in order to unleash their potential clinical benefits. This is because NPs can evolve toward different states, depending on the environment where they have been dispersed and how they have been dispersed. As a consequence, final characteristics of NPs can be very different from what was initially designed and produced in the laboratory. Thus, aggregation, corrosion, and interaction with extracellular matrix proteins critically modify NP features and fate. These modifications depend to a large extent on the characteristics of the biological media in which the NPs are dispersed. As a consequence, when reviewing the scientific literature, it seems that the aggregation state of NPs, which depends on the characteristics of the dispersing media, may be more significant than the composition or original size of the NPs. In this work, we focus on CeO NPs, which are reported sometimes to be protective and anti-inflammatory, and sometimes toxic and pro-inflammatory.
Nota:	Número d'acord de subvenció ISCIII/PI15/00777
Nota:	Número d'acord de subvenció MINECO/SAF2015-6412-R
Nota:	Número d'acord de subvenció EC/FP7/604602
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	article ; recerca ; publishedVersion
Materia:	Nanoparticles ; Cerium oxide
Publicado en:	Frontiers in immunology, Vol. 8 (August 2017) , art. 970, ISSN 1664-3224

Corrigendum: https://ddd.uab.cat/record/204860
DOI: 10.3389/fimmu.2017.00970
PMID: 28855907

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
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