Detoxifying antitumoral drugs via nanoconjugation : The case of gold nanoparticles and cisplatin
Comenge Farré, Joan (Institut Català de Nanociència i Nanotecnologia)
Sotelo, Carmen (Universidad de Santiago de Compostela. Departamento de Fisiología)
Romero, Francisco (Universitat de València. Instituto de Ciencia Molecular)
Gallego Rubio, Oscar (Institut d'Investigació Biomèdica Sant Pau)
Barnadas i Molins, Agustí (Institut d'Investigació Biomèdica Sant Pau)
García Caballero Parada, Tomás (Universidade de Santiago de Compostela. Departamento de Ciencias Morfolóxicas)
Domínguez Puente, Fernando (Universidad de Santiago de Compostela. Departamento de Fisiología)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Universitat Autònoma de Barcelona

Date:	2012
Abstract:	Nanoparticles (NPs) have emerged as a potential tool to improve cancer treatment. Among the proposed uses in imaging and therapy, their use as a drug delivery scaffold has been extensively highlighted. However, there are still some controversial points which need a deeper understanding before clinical application can occur. Here the use of gold nanoparticles (AuNPs) to detoxify the antitumoral agent cisplatin, linked to a nanoparticle via a pH-sensitive coordination bond for endosomal release, is presented. The NP conjugate design has important effects on pharmacokinetics, conjugate evolution and biodistribution and results in an absence of observed toxicity. Besides, AuNPs present unique opportunities as drug delivery scaffolds due to their size and surface tunability. Here we show that cisplatin-induced toxicity is clearly reduced without affecting the therapeutic benefits in mice models. The NPs not only act as carriers, but also protect the drug from deactivation by plasma proteins until conjugates are internalized in cells and cisplatin is released. Additionally, the possibility to track the drug (Pt) and vehicle (Au) separately as a function of organ and time enables a better understanding of how nanocarriers are processed by the organism.
Grants:	Ministerio de Economía y Competitividad MAT2009-14734-C02-01 Ministerio de Economía y Competitividad MAT2009-14734-C02-02 Ministerio de Educación y Ciencia CSD2006-00012 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-776
Note:	Altres ajuts: Generalitat de Catalunya VALTEC09-2-0085 i VALTEC09-2-0089
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 7, Issue 10 (October 2012) , art. e47562, ISSN 1932-6203

DOI: 10.1371/journal.pone.0047562
PMID: 23082177

16 p, 1.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles