Web of Science: 2 citations, Scopus: 2 citations, Google Scholar: citations,
Canine Leishmaniasis progression is associated with vitamin D deficiency
Rodríguez-Cortes, Alheli (Universitat Autònoma de Barcelona. Departament de Farmacologia, Terapèutica i Toxicologia)
Martori Muntsant, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, Terapèutica i Toxicologia)
Martinez-Florez, Alba (Universitat Autònoma de Barcelona. Departament de Farmacologia, Terapèutica i Toxicologia)
Clop, Alex (Centre de Recerca en Agrigenòmica)
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Kubejko, J. (Centre de Recerca en Agrigenòmica)
Llull, J. (Clínica veterinaria Mon Veterinari (Manacor, Balears))
Nadal, J.M. (Clínica veterinaria Mon Veterinari (Manacor, Balears))
Alberola, Jordi (Alberola i Domingo) (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Date: 2017
Abstract: The relationship between vitamin D deficiency and the risk of suffering from a plethora of health disorders, ranging from autoimmune processes to infectious diseases has been widely described. Nonetheless, the potential role of vitamin D in visceral leishmaniasis remains uncharacterized. In the Mediterranean basin, where the dog is leishmania's main peri-domestic reservoir, control measures against the canine disease have shown beneficial effects on the incidence of human leishmaniasis. In this study, we measured the vitamin D levels in serum samples from a cohort of 68 healthy and disease dogs from a highly endemic area and we have also studied the relationship of these levels with parasitological and immunological parameters. The sick dogs presented significantly lower (P<0. 001) vitamin D levels (19. 6ng/mL) than their non-infected (31. 8ng/mL) and the asymptomatic counterparts (29. 6ng/mL). In addition, vitamin D deficiency correlated with several parameters linked to leishmaniasis progression. However, there was no correlation between vitamin D levels and the Leishmania-specific cellular immune response. Moreover, both the leishmanin skin test and the IFN-γ levels displayed negative correlations with serological, parasitological and clinical signs. Further studies to determine the functional role of vitamin D on the progression and control of canine leishmaniasis are needed.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: Scientific Reports, Vol. 7 (2017) , art. 3346, ISSN 2045-2322

DOI: 10.1038/s41598-017-03662-4
PMID: 28611427

10 p, 1.5 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2019-06-18, last modified 2019-09-30

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