Web of Science: 4 cites, Scopus: 4 cites, Google Scholar: cites,
Critical features of acute stress induced cross-sensitization identified through the hypothalamic-pituitary-adrenal axis output
Belda Poyato, Francisco Javier (Universitat Autònoma de Barcelona. Unitat de Fisiologia animal)
Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)
Armario García, Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències)

Data: 2016
Resum: Stress-induced sensitization represents a process whereby prior exposure to severe stressors leaves animals or humans in a hyper-responsive state to further stressors. Indeed, this phenomenon is assumed to be the basis of certain stress-associated pathologies, including post-traumatic stress disorder and psychosis. One biological system particularly prone to sensitization is the hypothalamic-pituitary-adrenal (HPA) axis, the prototypic stress system. It is well established that under certain conditions, prior exposure of animals to acute and chronic (triggering) stressors enhances HPA responses to novel (heterotypic) stressors on subsequent days (e. g. raised plasma ACTH and corticosterone levels). However, such changes remain somewhat controversial and thus, the present study aimed to identify the critical characteristics of the triggering and challenging stressors that affect acute stress-induced HPA cross-sensitization in adult rats. We found that HPA cross-sensitization is markedly influenced by the intensity of the triggering stressor, whereas the length of exposure mainly affects its persistence. Importantly, HPA sensitization is more evident with mild than strong challenging stressors, and it may remain unnoticed if exposure to the challenging stressor is prolonged beyond 15 min. We speculate that heterotypic HPA sensitization might have developed to optimize biologically adaptive responses to further brief stressors.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Publicat a: Scientific Reports, Vol. 6 (August 2016) , art. 31244, ISSN 2045-2322

DOI: 10.1038/srep31244
PMID: 27511270


12 p, 1.5 MB

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