Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia)
Maldonado, Jesús (Institut Català de Nanociència i Nanotecnologia)
Herranz, Sonia (Institut Català de Nanociència i Nanotecnologia)
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)

Date:	2016
Abstract:	Portable point-of care (POC) devices for in vitro diagnostics will be a milestone for the achievement of universal healthcare and environmental protection. The main goal is to reach a rapid, user-friendly and highly sensitive portable tool which can provide immediate results in any place at any time while having a competitive cost. Integrated optical (IO) waveguide based-biosensors are the most suitable candidates to achieve this ambitious objective. They are able to operate in real samples (such as blood, urine, wastewater…) affording relevant sensitivities even under a label-free scheme. In addition, arrays of IO sensors for multiplexed analysis can be integrated in lab-on-chip (LOC) platforms, providing a truly cost-effective fabrication and miniaturization. Among the different IO biosensors, interferometric ones have demonstrated the highest sensitivity for label-free detection ever reported. Although the first interferometric biosensors were developed in the early nineties, they focused mainly on preliminary proof-of-concept studies; only recently the resilient potential of interferometric biosensors as highly advanced POC devices has firmly emerged. This review provides an overview of the state-of-the art in photonic interferometric biosensors, their main biofunctionalisation routes and their integration in LOC platforms, while maintaining a special focus on the real analytical applications achieved so far.
Grants:	Ministerio de Ciencia e Innovación TEC2012-34280 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-624 Ministerio de Economía y Competitividad SEV-2013-0295
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió sotmesa a revisió
Subject:	Analytical applications ; Biofunctionalisation ; Competitive costs ; Cost-effective fabrication ; In-vitro diagnostic ; Label-free detection ; Multiplexed analysis ; Point of care diagnostic
Published in:	Analytical methods, Vol. 8, Issue 48 (December 2016) , p. 8380-8394, ISSN 1759-9679

DOI: 10.1039/c6ay02972h

Preprint 17 p, 952.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
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