Nanophotonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers
Duval, Daphné (Institut Català de Nanociència i Nanotecnologia)
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia)
Dante, Stefania (Institut Català de Nanociència i Nanotecnologia)
Osmond, Johann (Institute of Photonic Sciences)
Monge, Rosa (Universidad de Zaragoza)
Fernández, Luis J. (Universidad de Zaragoza)
Zinoviev, K. E. (Microelectronics National Center)
Dominguez, Carlos (Microelectronics National Center)
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)

Data:	2012
Resum:	One of the main limitations for achieving truly lab-on-a-chip (LOC) devices for point-of-care diagnosis is the incorporation of the "on-chip" detection. Indeed, most of the state-of-the-art LOC devices usually require complex read-out instrumentation, losing the main advantages of portability and simplicity. In this context, we present our last advances towards the achievement of a portable and label-free LOC platform with highly sensitive "on-chip" detection by using nanophotonic biosensors. Bimodal waveguide interferometers fabricated by standard silicon processes have been integrated with sub-micronic grating couplers for efficient light in-coupling, showing a phase resolution of 6. 6 × 10 × 2π rad and a limit of detection of 3. 3 × 10 refractive index unit (RIU) in bulk. A 3D network of SU-8 polymer microfluidics monolithically assembled at the wafer-level was included, ensuring perfect sealing and compact packaging. To overcome some of the drawbacks inherent to interferometric read-outs, a novel all-optical wavelength modulation system has been implemented, providing a linear response and a direct read-out of the phase variation. Sensitivity, specificity and reproducibility of the wavelength modulated BiMW sensor has been demonstrated through the label-free immunodetection of the human hormone hTSH at picomolar level using a reliable biofunctionalization process.
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Publicat a:	Lab on a chip, Vol. 12, Issue 11 (May 2012) , p. 1987-1994, ISSN 1473-0189

DOI: 10.1039/c2lc40054e

Postprint 11 p, 910.6 KB

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