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Nanophotonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers
Duval, Daphné (Institut Català de Nanociència i Nanotecnologia)
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia)
Dante, Stefania (Institut Català de Nanociència i Nanotecnologia)
Osmond, Johann (Institute of Photonic Sciences)
Monge, Rosa (Universidad de Zaragoza)
Fernández, Luis J. (Universidad de Zaragoza)
Zinoviev, K.E. (Microelectronics National Center)
Dominguez, Carlos (Microelectronics National Center)
Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)

Date: 2012
Abstract: One of the main limitations for achieving truly lab-on-a-chip (LOC) devices for point-of-care diagnosis is the incorporation of the "on-chip" detection. Indeed, most of the state-of-the-art LOC devices usually require complex read-out instrumentation, losing the main advantages of portability and simplicity. In this context, we present our last advances towards the achievement of a portable and label-free LOC platform with highly sensitive "on-chip" detection by using nanophotonic biosensors. Bimodal waveguide interferometers fabricated by standard silicon processes have been integrated with sub-micronic grating couplers for efficient light in-coupling, showing a phase resolution of 6. 6 × 10 × 2π rad and a limit of detection of 3. 3 × 10 refractive index unit (RIU) in bulk. A 3D network of SU-8 polymer microfluidics monolithically assembled at the wafer-level was included, ensuring perfect sealing and compact packaging. To overcome some of the drawbacks inherent to interferometric read-outs, a novel all-optical wavelength modulation system has been implemented, providing a linear response and a direct read-out of the phase variation. Sensitivity, specificity and reproducibility of the wavelength modulated BiMW sensor has been demonstrated through the label-free immunodetection of the human hormone hTSH at picomolar level using a reliable biofunctionalization process.
Rights: Tots els drets reservats.
Language: Anglès
Document: article ; recerca ; Versió acceptada per publicar
Published in: Lab on a chip, Vol. 12, Issue 11 (May 2012) , p. 1987-1994, ISSN 1473-0189

DOI: 10.1039/c2lc40054e

11 p, 910.6 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2019-07-22, last modified 2021-06-12

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