Full integration of photonic nanoimmunosensors in portable platforms for on-line monitoring of ocean pollutants
Fernandez-Gavela, Adrian (Institut Català de Nanociència i Nanotecnologia)
Herranz, Sonia (Institut Català de Nanociència i Nanotecnologia)
Chocarro Ruiz, Blanca (Institut Català de Nanociència i Nanotecnologia)
Falke, Floris (Lionix International)
Schreuder, Erik (Lionix International)
Leeuwis, Henz (Lionix International)
Heideman, René G. (Lionix International)
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)

Data:	2019
Resum:	We have developed a photonic nano-immunosensor platform for the on-site analysis of harmful organic ocean pollutants, intended to be allocated in stand-alone buoys. The main aim is bringing the monitoring tools directly to the contaminated place, resulting in cost and time savings as compared to the standard analytical techniques. As sensor we have employed an integrated asymmetric Mach-Zehnder interferometer (aMZI) of micro/nano dimensions, based on silicon photonic technology. In order to obtain a multiplexed system, a four-channel microfluidic cell has been designed, manufactured and incorporated in the miniaturized sensor. Additionally, a microfluidic delivery module enabling automatic sample analysis has been designed, evaluated and assembled. Moreover, we have implemented the optical interconnections of the sensor chip by fiber optics, as well the electronics and the required software and data processing. Pollutant detection is based on a competitive immunoassay using bioreceptors previously biofunctionalized on the aMZI sensor arms and incubation with a specific antibody. As proof of concept, two types of pollutants have been analysed: the biocide Irgarol 1051, and the antibiotic Tetracycline. Results show limits of detection in the range of few ng/mL, accomplished the European legislation.
Ajuts:	European Commission 614010 Ministerio de Economía y Competitividad SEV-2013-0295
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Optical biosensor ; Lab-on-a-chip ; Integrated optics ; Microfluidics ; Ocean pollution
Publicat a:	Sensors and actuators. B, Chemical, Vol. 297 (2019) , art. 126758, ISSN 1873-3077

DOI: 10.1016/j.snb.2019.126758

Postprint 22 p, 863.8 KB

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