Patterns of homozygosity in insular and continental goat breeds
Cardoso, Tainã Figueiredo (Centre de Recerca en Agrigenòmica)
Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica)
Bertolini, Francesca (Iowa State University. Department of Animal Science)
Rothschild, Max (Iowa State University. Department of Animal Science)
Marras, Gabriele (Fondazione Parco Tecnologico Padano. Bioinformatics Core Facility)
Boink, Geert (Stichting Zeldzame Huisdierrassen)
Jordana i Vidal, Jordi (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Capote, Juan (Instituto Canario de Investigaciones Agrarias)
Carolan, Sean (The Old Irish Goat Society)
Hallsson, Jón H. (Agricultural University of Iceland. Faculty of Land and Animal Resources)
Kantanen, Juha (Natural Resources Institute Finland. Department of Production Systems)
Pons Barro, Agueda L. (Servei de Millora Agrària i Pesquera (SEMILLA). Unitat de Races Autòctones)
Lenstra, Johannes A. (Utrecht University. Faculty of Veterinary Medicine)

Date:	2018
Abstract:	Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals from 25 European and African breeds with the Goat SNP50 BeadChip and comparing patterns of homozygosity of insular and nearby continental breeds. Among the breeds analysed, number and total length of ROH varied considerably and depending on breeds, ROH could cover a substantial fraction of the genome (up to 1. 6 Gb in Icelandic goats). When compared with their continental counterparts, goats from Iceland, Madagascar, La Palma and Ireland (Bilberry and Arran) displayed a significant increase in ROH coverage, ROH number and F values (P value < 0. 05). Goats from Mediterranean islands represent a more complex case because certain populations displayed a significantly increased level of homozygosity (e. g. Girgentana) and others did not (e. g. Corse and Sarda). Correlations of number and total length of ROH for insular goat populations with the distance between islands and the nearest continental locations revealed an effect of extremely long distances on the patterns of homozygosity. These results indicate that the effects of insularization on the patterns of homozygosity are variable. Goats raised in Madagascar, Iceland, Ireland (Bilberry and Arran) and La Palma, show high levels of homozygosity, whereas those bred in Mediterranean islands display patterns of homozygosity that are similar to those found in continental populations. These results indicate that the diversity of insular goat populations is modulated by multiple factors such as geographic distribution, population size, demographic history, trading and breed management. The online version of this article (10. 1186/s12711-018-0425-7) contains supplementary material, which is available to authorized users.
Grants:	Ministerio de Ciencia e Innovación AGL2016-76108-R Ministerio de Ciencia e Innovación SEV-2015-0533
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Genetics, selection, evolution, Vol. 50 (november 2018) , ISSN 1297-9686

DOI: 10.1186/s12711-018-0425-7
PMID: 30449277

11 p, 2.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > CRAG (Centre for Research in Agricultural Genomics)
Articles > Research articles
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