Web of Science: 18 citations, Scopus: 19 citations, Google Scholar: citations,
Linear readout of integrated interferometric biosensors using a periodic wavelength modulation
Dante, Stefania (Institut Català de Nanociència i Nanotecnologia)
Duval, Daphné (Institut Català de Nanociència i Nanotecnologia)
Fariña, David (Institut Català de Nanociència i Nanotecnologia)
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia)
Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)

Date: 2015
Abstract: An all-optical phase modulation method for the linear readout of integrated interferometric biosensors is demonstrated, merging simple intensity detection with the advantages offered by spectral interrogation. The phase modulation is introduced in a simple and cost-effective way by tuning a few nanometers the emission wavelength of commercial laser diodes, taking advantage of their well-known drawback of power-wavelength dependence. The method is applied to the case of a bimodal waveguide (BiMW) interferometric biosensor, fabricated with standard silicon technology and operated at visible wavelengths, rendering a detection limit of 4×10-7 refractive index units for bulk sensing. The biosensing capabilities of the phase-linearized BiMW device are assessed through the quantitative immunoassay of C-reactive protein, a key protein in inflammatory processes. This method can be applied to any modal interferometer. To solve the ambiguities affecting interferometric biosensors, a phase modulation system based on variations of the incident wavelength and Fourier deconvolution is presented. The wavelength variation is introduced taking advantage of the power-wavelength dependence of commercial laser diodes, resulting in a cost-effective method, valid for all modal interferometers. Considering the modulation of a bimodal waveguide interferometric sensor, limits of detection of 4 · 10 for bulk sensing and 7 ng/ml for the detection of C-Reactive protein were demonstrated.
Note: Número d'acord de subvenció MICINN/TEC2012-34280
Note: Número d'acord de subvenció MEC/FPU/AP2009-1739
Rights: Tots els drets reservats.
Language: Anglès.
Document: article ; recerca ; acceptedVersion
Subject: Biosensor ; Integrated optics ; Interferometer ; Linear readout ; Phase modulation
Published in: Laser and photonics reviews, Vol. 9, Issue 2 (March 2015) , p. 248-255, ISSN 1863-8899

DOI: 10.1002/lpor.201400216


Postprint
15 p, 4.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles

 Record created 2019-09-23, last modified 2020-02-29



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