Cerebral gliosarcoma with perivascular involvement in a cat
Álvarez, Patricia (Pride Veterinary Centre, Derby. Neurology and Neurosurgery Service)
Wessmann, Annette ![Identificador ORCID](/img/uab/orcid.ico)
(Pride Veterinary Centre, Derby. Neurology and Neurosurgery Service)
Pascual, Mireia (BalmesVet. ClínicaVeterinaria (Barcelona))
Comas Solé, Oriol (BalmesVet. ClínicaVeterinaria (Barcelona))
Pi Castro, Dolors ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pumarola i Batlle, Martí ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Data: |
2019 |
Resum: |
Case summary A 5-year-old neutered male domestic shorthair cat presented with an 18-month history of facial tics, and progressive general ataxia, weakness, lethargy and anorexia of 2 weeks' duration. MRI of the brain showed a well-defined heterogeneous hyperintense mass on T1-weighted and T2-weighted images, with central hypointensity in the rostral commissure and septum pellucidum, and perilesional hyperintensity in fluid-attenuated inversion recovery, suggestive of perilesional oedema. Gross examination in a transverse section of the brain at the level of the septum pellucidum revealed a 0. 2 cm brown soft mass. Histopathological examination identified a biphasic neoplastic proliferation of mesenchymal and neuroepithelial cell populations. Fusiform cells were predominately distributed in bundles showing a high degree of anisocytosis and marked immune-positive reaction to vimentin immunochemistry, confirming a sarcomatous origin. Additionally, high numbers of astrocytic cells were identified by an intense immunopositive reaction to glial fibrillary acidic protein and negative reaction to oligodendrocyte transcription factor 2 immunochemistry. Vascular invasion of the neoplasia into the wall of a medium branch of the rostral cerebral artery was present (secondary Scherer structures). Based on these characteristics, the tumour was defined as a gliosarcoma. Gliosarcoma is a recognised astrocytoma grade IV anaplastic glial cell tumour with sarcomatous differentiation. Relevance and novel information To our knowledge, this is the first report describing a cerebral gliosarcoma in a cat including clinical, MRI, macroscopic and histopathological features and immunolabelling characteristics. |
Drets: |
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Llengua: |
Català |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
Brain ;
Neoplasia ;
Glioma ;
Histopathology ;
Immunohistochemistry ;
Scherer structures ;
MRI |
Publicat a: |
Journal of feline medicine and surgery, Vol. 5, Num. 2 (2019) , ISSN 1532-2750 |
Adreça alternativa: https://scholar.google.cat/scholar?q=Álvarez+Cerebral+gliosarcoma+with+perivascular+involvement
DOI: 10.1177/2055116919879783
PMID: 31636916
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Registre creat el 2019-10-31, darrera modificació el 2023-03-30