The role of exosomes in the metastatic cascade and the pre-metastatic niche formation
Pintado Grima, Carlos
Bassols Teixidó, Anna Maria, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Universitat Autònoma de Barcelona. Facultat de Biociències

Data: 2019
Resum: Cancer is one the most incident diseases in our society that contributes to 9 million fatalities a year in the world, being metastasis the key stage that accounts for 90% of all cancer-associated deaths. Many efforts have been put in finding the mechanisms and processes underlying cancer metastasis to design new approaches in diagnosis and therapies that could improve the treatment of this complex disease. Tumor derived exosomes have been described as important regulatory components in all steps involved in the metastatic cascade which modulates the development of tumors, invasiveness and colonization. The delivery of specific biomolecules contained within these exosomes modify the recipient targeted cells and the environment, contributing to the development of an optimal pre-metastatic niche for tumor colonization. The fact that tumor derived exosomes are involved in every single step of the metastatic cascade has put them under the light as potential biomarkers for a better diagnosis, but also as effective drug delivers and targets. This project aims to show the importance of these exosomes in metastasis and pre-metastatic niche formation and their feasibility of becoming an important component in the whole cancer story in a close future.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Titulació: Biologia [2500250]
Pla d'estudis: Grau en Biologia [812]
Document: bachelorThesis ; Text
Matèria: Exosomes ; Metastasis ; Pre-metastatic niche ; Tumor environment ; Diagnosis ; Therapy



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Documents de recerca > Treballs de Fi de Grau > Facultat de Biociències. TFG

 Registre creat el 2019-11-21, darrera modificació el 2021-06-06



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