Web of Science: 6 cites, Scopus: 6 cites, Google Scholar: cites,
Genetic variation in pan species is shaped by demographic history and harbors lineage-specific functions
Han, Sojung (Institut de Biologia Evolutiva)
Andrés, Aida M. (UCL Genetics Institute)
Marquès i Bonet, Tomàs, 1975- (Institut Català de Paleontologia Miquel Crusafont)
Kuhlwilm, Martin (Institut de Biologia Evolutiva)
Universitat Autònoma de Barcelona

Data: 2019
Resum: Chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) are the closest living relatives of humans, but the two species show distinct behavioral and physiological differences, particularly regarding female reproduction. Despite their recent rapid decline, the demographic histories of the two species have been different during the past 1-2 Myr, likely having an impact on their genomic diversity. Here, we analyze the inferred functional consequences of genetic variation across 69 individuals,making use of themost complete data set of genomes in the Pan clade to date. We test towhich extent the demographic history influences the efficacy of purifying selection in these species. We find that small historical effective population sizes (Ne) correlate not only with low levels of genetic diversity but also with a larger number of deleterious alleles in homozygosity and an increased proportion of deleterious changes at lowfrequencies. Toinvestigate the putativegeneticbasis forphenotypic differencesbetweenchimpanzees andbonobos, we exploit the catalog of putatively deleterious protein-coding changes in each lineage. We show that bonobo-specific nonsynonymous changes are enrichedin genes relatedtoage atmenarche inhumans, suggesting that the prominent physiologicaldifferences in the female reproductive systembetweenchimpanzees andbonobosmightbe explained, inpart,byputatively adaptive changeson the bonobo lineage.
Nota: Número d'acord de subvenció MINECO/BFU2017-86471-P
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Bonobo genome ; Bonobo reproduction ; Comparative genomics ; Deleteriousness
Publicat a: Genome biology and evolution, Vol. 11, Issue 4 (April 2019) , p. 1178-1191, ISSN 1759-6653

DOI: 10.1093/gbe/evz047
PMID: 30847478


14 p, 627.9 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > Institut Català de Paleontologia Miquel Crusafont (ICP)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2019-11-27, darrera modificació el 2019-12-23



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