Web of Science: 64 citations, Scopus: 66 citations, Google Scholar: citations,
Two-photon neuronal and astrocytic stimulation with azobenzene-based photoswitches
Izquierdo Serra, Mercè (Institut de Bioenginyeria de Catalunya)
Gascón Moya, Marta (Universitat Autònoma de Barcelona. Departament de Química)
Hirtz, Jan J. (Columbia University. Department of Biological Sciences)
Pittolo, Silvia (Institut de Bioenginyeria de Catalunya)
Poskanzer, Kira E. (Columbia University. Department of Biological Sciences)
Ferrer Mallofré, Èric (Universitat Autònoma de Barcelona. Departament de Química)
Alibés Arqués, Ramon (Universitat Autònoma de Barcelona. Departament de Química)
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química)
Yuste, Rafael (Columbia University. Department of Biological Sciences)
Hernando Campos, Jordi (Universitat Autònoma de Barcelona. Departament de Química)
Gorostiza, Pau (Institut de Bioenginyeria de Catalunya)

Date: 2014
Abstract: Synthetic photochromic compounds can be designed to control a variety of proteins and their biochemical functions in living cells, but the high spatiotemporal precision and tissue penetration of two-photon stimulation have never been investigated in these molecules. Here we demonstrate two-photon excitation of azobenzene-based protein switches and versatile strategies to enhance their photochemical responses. This enables new applications to control the activation of neurons and astrocytes with cellular and subcellular resolution.
Note: This is an open access article published under an ACS AuthorChoice License. See Standard ACS AuthorChoice/Editors' Choice Usage Agreement - https://pubs.acs.org/page/policy/authorchoice_termsofuse.html
Note: Número d'acord de subvenció EC/FP7/210355
Note: Número d'acord de subvenció EC/FP7/335011
Note: Número d'acord de subvenció EC/FP7/270483
Note: Número d'acord de subvenció AGAUR/2009/SGR-277
Note: Número d'acord de subvenció AGAUR/2012/FI_B 01122
Note: Número d'acord de subvenció MINECO/CTQ2008-06160
Note: Número d'acord de subvenció MINECO/CTQ2012-30853
Note: Número d'acord de subvenció MINECO/CTQ2010-15380
Rights: Tots els drets reservats.
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Biochemical functions ; New applications ; Photochemical response ; Photochromic compound ; Protein switches ; Subcellular resolution ; Tissue penetrations ; Two-photon excitations ; Azo Compounds ; Cells, Cultured ; HEK293 Cells ; Humans ; Molecular Structure ; Photochemical Processes ; Proteins ; Protons
Published in: Journal of the American Chemical Society, Vol. 136, Issue 24 (June 2014) , p. 8693-8701, ISSN 1520-5126

DOI: 10.1021/ja5026326
PMID: 24857186


9 p, 2.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Experimental sciences > Group in Electrochemistry, Photochemistry and Organic Reactivity (GEFRO)
Articles > Research articles
Articles > Published articles

 Record created 2019-12-10, last modified 2020-08-02



   Favorit i Compartir