Genetic testing to predict weight loss and diabetes remission and long-term sustainability after bariatric surgery : a pilot study
Ciudin, Andreea (Hospital Universitari Vall d'Hebron)
Fidilio, Enzamaria (Vall d'Hebron Institut de Recerca (VHIR))
Ortiz Zúñiga, Ángel Michael (Vall d'Hebron Institut de Recerca (VHIR))
Pich, Sara (Hospital Universitari Joan XXIII de Tarragona)
Salas, Eduardo (Hospital Universitari Joan XXIII de Tarragona)
Mesa Manteca, Jordi (Hospital Universitari Vall d'Hebron)
Hernández, Cristina (Vall d'Hebron Institut de Recerca (VHIR))
Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina)
Lecube, Albert (Hospital Arnau de Vilanova (Lleida, Catalunya))
Simó Canonge, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)

Data:	2019
Resum:	Introduction: The aim of this pilot study was to assess genetic predisposition risk scores (GPS) in type 2 diabetic and non-diabetic patients in order to predict the better response to bariatric surgery (BS) in terms of either weight loss or diabetes remission. Research Design and Methods: A case-control study in which 96 females (47 with type 2 diabetes) underwent Roux-en-Y gastric by-pass were included. The DNA was extracted from saliva samples and SNPs were examined and grouped into 3 GPS. ROC curves were used to calculate sensitivity and specificity. Results: A highly sensitive and specific predictive model of response to BS was obtained by combining the GPS in non-diabetic subjects. This combination was different in diabetic subjects and highly predictive of diabetes remission. Additionally, the model was able to predict the weight regain and type 2 diabetes relapse after 5 years' follow-up. Conclusions: Genetic testing is a simple, reliable and useful tool for implementing personalized medicine in type 2 diabetic patients equiring BS.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Diabetes ; Obesity ; Bariatric surgery
Publicat a:	Journal of clinical medicine, Vol. 8 (2019) , p. 1-8, ISSN 2077-0383

DOI: 10.3390/jcm8070964
PMID: 31277226

8 p, 1.2 MB

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