Web of Science: 15 cites, Scopus: 18 cites, Google Scholar: cites,
One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
Zeljenková, Dagmar (Slovak Medical University in Bratislava)
Aláčová, Radka (Slovak Medical University in Bratislava)
Ondrejková, Júlia (Slovak Medical University in Bratislava)
Ambrušová, Katarína (Slovak Medical University in Bratislava)
Bartušová, Mária (Slovak Medical University in Bratislava)
Kebis, Anton (Slovak Medical University in Bratislava)
Kovrižnych, Jevgenij (Slovak Medical University in Bratislava)
Rollerova, Eva (Slovak Medical University in Bratislava)
Szabová, Elena (Slovak Medical University in Bratislava)
Wimmerová, Sona (Slovak Medical University in Bratislava)
Černák, Martin (Slovak Medical University in Bratislava)
Krivošíková, Zora (Slovak Medical University in Bratislava)
Kuricová, Miroslava (Slovak Medical University in Bratislava)
Líšková, Aurélia (Slovak Medical University in Bratislava)
Spustová, Viera (Slovak Medical University in Bratislava)
Tulinská, Jana (Slovak Medical University in Bratislava)
Levkut, Mikuláš (University of Veterinary Medicine and Pharmacy in Košice and TOPALAB)
Révajová, Viera (University of Veterinary Medicine and Pharmacy in Košice and TOPALAB)
Ševčíková, Zuzana (University of Veterinary Medicine and Pharmacy in Košice and TOPALAB)
Schmidt, Kerstin (BioMath GmbH (Germany))
Schmidtke, Jörg (BioMath GmbH (Germany))
Schmidt, Paul (BioMath GmbH (Germany))
La Paz, Jose Luis (Centre de Recerca en Agrigenòmica)
Corujo, Maria (Centre de Recerca en Agrigenòmica)
Pla, Maria (Universitat de Girona)
Kleter, Gijs A. (Wageningen University and Research Centre. RIKILT Wageningen UR)
Kok, Esther J. (Wageningen University and Research Centre. RIKILT Wageningen UR)
Sharbati, Jutta (Freie Universität Berlin. Institute of Veterinary Biochemistry)
Bohmer, Marc (Freie Universität Berlin. Institute of Veterinary Biochemistry)
Bohmer, Nils (Freie Universität Berlin. Institute of Veterinary Biochemistry)
Einspanier, Ralf (Freie Universität Berlin. Institute of Veterinary Biochemistry)
Adel-Patient, Karine (Institut national de la recherche agronomique. Unité d'Immuno-Allergie Alimentaire)
Spök, Armin (IFZ-Inter-University Research Centre for Technology. Work and Culture)
Pöting,Annette (Federal Institute for Risk Assessment)
Kohl, Christian (Julius Kühn-Institut. Institute for Biosafety in Plant Biotechnology)
Wilhelm, Ralf (Julius Kühn-Institut. Institute for Biosafety in Plant Biotechnology)
Schiemann, Joachim (Julius Kühn-Institut. Institute for Biosafety in Plant Biotechnology)
Steinberg, Pablo (University of Veterinary Medicine Hannover. Institute for Food Toxicology and Analytical Chemistry)

Data: 2016
Resum: The GRACE (GMO Risk Assessment and Communication of Evidence; www. grace-fp7. eu) project was funded by the European Commission within the 7th Framework Programme. A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure.
Nota: Número d'acord de subvenció EC/FP7/311957
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; recerca ; publishedVersion
Matèria: Food/Feed Guidance Document of the EFSA Scientific Committee (2011) ; Genetically modified maize MON810 ; GRACE ; OECD Test Guideline No. 452-Chronic toxicity studies (2009) ; Rat feeding trial ; Chronic oral toxicity study
Publicat a: Archives of Toxicology, Vol. 90, Issue 10 (October 2016) , p. 2531-2562, ISSN 1432-0738

DOI: 10.1007/s00204-016-1798-4
PMID: 27439414


32 p, 2.6 MB

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