Sustainable synthesis of luminescent CdTe quantum dots coated with modified silica mesoporous nanoparticles : Towards new protein scavengers and smart drug delivery carriers
Oliveira, Elisabete (Proteomass Scientific Society)
Santos, Hugo M. (Proteomass Scientific Society)
Jorge, Susana (Proteomass Scientific Society)
Rodríguez-González, Benito (Scientific and Technological Research Assistance Centre)
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia)
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Capelo-Martínez, José Luis (Proteomass Scientific Society)
Lodeiro, Carlos (Proteomass Scientific Society)

Date:	2019
Abstract:	The synthesis and full characterization of a family of sustainable luminescent nanoparticles, CdTeQDs@MNs, made of quantum dots coated by modified mesoporous silica nanoparticles is reported. The presence of the luminescent QDs allows the imaging of the nanoparticles during cell internalization, as well as the visualization of selective release of doxorubicin inside the cell (via pH stimuli). The modified mesoporous silica nanoparticles lead to pore size improvement allowing better encapsulation and controlled release, of different active principles studied such as, small molecules (rhodamine B), drugs (doxorubicin), and isolated proteins such as bovine serum albumin, lysozyme, carbonic anhydrase, ovalbumin, α-lactalbumin, hemoglobin, myoglobin and cytochrome C. Finally, and as a proof-of-concept the efficacy of these novel platforms was demonstrated through the successful extraction and recognition of proteins in raw serum of osteoarthritis and prosthesis patients, without any previous protein depletion.
Grants:	Ministerio de Economía y Competitividad MAT2015-70615-R Ministerio de Economía y Competitividad SEV-2013-0295 Ministerio de Economía y Competitividad BIO2016-08057-R
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió sotmesa a revisió
Subject:	Luminescence ; Quantum dots ; Mesoporous silica nanoparticles ; Doxorubicin ; Proteins ; Nanoproteomics
Published in:	Dyes and pigments, Vol. 161 (February 2019) , p. 360-369, ISSN 1873-3743

DOI: 10.1016/j.dyepig.2018.09.047

Preprint 34 p, 1.7 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles