In Vivo Osteogenic Potential of Biomimetic hydroxyapatite/Collagen Microspheres : Comparison with Injectable Cement Pastes
Silva Cuzmar, Erika (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Franch, Jordi (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pérez, Roman A. (Universitat Politècnica de Catalunya)
Manzanares, María Cristina (Universitat de Barcelona)
Ginebra, Maria-Pau (Universitat Politècnica de Catalunya)

Data:	2015
Resum:	The osteogenic capacity of biomimetic calcium deficient hydroxyapatite microspheres with and without collagen obtained by emulsification of a calcium phosphate cement paste has been evaluated in an in vivo model, and compared with an injectable calcium phosphate cement with the same composition. The materials were implanted into a 5 mm defect in the femur condyle of rabbits, and bone formation was assessed after 1 and 3 months. The histological analysis revealed that the cements presented cellular activity only in the margins of the material, whereas each one of the individual microspheres was covered with osteogenic cells. Consequently, bone ingrowth was enhanced by the microspheres, with a tenfold increase compared to the cement, which was associated to the higher accessibility for the cells provided by the macroporous network between the microspheres, and the larger surface area available for osteoconduction. No significant differences were found in terms of bone formation associated with the presence of collagen in the materials, although a more extensive erosion of the collagen-containing microspheres was observed.
Ajuts:	Ministerio de Economía y Competitividad MAT2012-38438-C03-02
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Fosfats de calci ; Ciments ossis ; Biomaterials ; Biomimetics
Publicat a:	PloS one, Vol. 10 Núm. 7 (Juliol 2015) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0131188
PMID: 26132468

15 p, 12.8 MB

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