Polydopamine-like Coatings as Payload Gatekeepers for Mesoporous Silica Nanoparticles
Moreno Villaécija, Miguel Ángel (Institut Català de Nanociència i Nanotecnologia)
Sedó Vegara, Josep (Institut Català de Nanociència i Nanotecnologia)
Guisasola, Eduardo (Universidad Complutense de Madrid. Departamento de Química Inorgánica)
Baeza, Alejandro (Universidad Complutense de Madrid. Departamento de Química Inorgánica)
Vallet Regí, María (Universidad Complutense de Madrid. Departamento de Química Inorgánica)
Nador, Fabiana (Universidad Nacional del Sur)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)

Date:	2018
Abstract:	We report the use of bis-catecholic polymers as candidates for obtaining effective, tunable gatekeeping coatings for mesoporous silica nanoparticles (MSNs) intended for drug release applications. In monomers, catechol rings act as adhesive moieties and reactive sites for polymerization, together with middle linkers which may be chosen to tune the physicochemical properties of the resulting coating. Stable and low-toxicity coatings (pNDGA and pBHZ) were prepared from two bis-catechols of different polarity (NDGA and BHZ) on MSN carriers previously loaded with rhodamine B (RhB) as a model payload, by means of a previously reported synthetic methodology and without any previous surface modification. Coating robustness and payload content were shown to depend significantly on the workup protocol. The release profiles in a model physiological PBS buffer of coated systems (RhB@MSN@pNDGA and RhB@MSN@pBHZ) showed marked differences in the "gatekeeping" behavior of each coating, which correlated qualitatively with the chemical nature of their respective linker moieties. While the uncoated system (RhB@MSN) lost its payload almost completely after 2 days, release from RhB@MSN@pNDGA was virtually negligible, likely due to the low polarity of the parent bis-catechol (NDGA). As opposed to these extremes, RhB@MSN@pBHZ presented the most promising behavior, showing an intermediate release of 50% of the payload in the same period of time.
Grants:	Ministerio de Economía y Competitividad MAT2015-70615-R Ministerio de Economía y Competitividad MAT2015-64831-R Ministerio de Economía y Competitividad SEV-2013-0295 European Commission 694160
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Chemical nature ; Coated systems ; Mesoporous silica nanoparticles ; Physicochemical property ; Polydopamine ; Reactive site ; Release profiles ; Synthetic methodology ; Indoles ; Nanoparticles ; Polymers ; Porosity ; Silicon Dioxide
Published in:	ACS applied materials & interfaces, Vol. 10, Issue 9 (March 2018) , p. 7661-7669, ISSN 1944-8252

DOI: 10.1021/acsami.7b08584

Postprint 34 p, 1002.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles