Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
Hendriksen, Rene S. (National Food Institute. Technical University of Denmark)
Munk, Patrick (Technical University of Denmark. National Food Institute.)
Njage, Patrick (Technical University of Denmark. National Food Institute.)
van Bunnik, Bram (University of Edinburgh. Usher Institute.)
McNally, Luke (University of Edinburgh. Centre for Synthetic and Systems Biology. School of Biological Sciences.)
Lukjancenko, Oksana (Technical University of Denmark. National Food Institute.)
Röder, Timo (Technical University of Denmark. National Food Institute.)
Nieuwenhuijse, David (Erasmus Medical Center. Viroscience.)
Pedersen, Susanne Karlsmose (Technical University of Denmark. National Food Institute.)
Kjeldgaard, Jette (Technical University of Denmark. National Food Institute.)
Kaas, Rolf S. (Technical University of Denmark. National Food Institute.)
Clausen, Philip Thomas Lanken Conradsen (Technical University of Denmark. National Food Institute.)
Vogt, Josef Korbinian (Technical University of Denmark. National Food Institute.)
Leekitcharoenphon, Pimlapas (Technical University of Denmark. National Food Institute.)
van de Schans, Milou G. M. (RIKILT Wageningen University and Research)
Zuidema, Tina (RIKILT Wageningen University and Research)
de Roda Husman, Ana Maria (National Institute for Public Health and the Environment (RIVM))
Rasmussen, Simon (Technical University of Denmark. Department of Bio and Health Informatics.)
Petersen, Bent (Technical University of Denmark. Department of Bio and Health Informatics.)
Bego, Artan (Institute of Public Health)
Rees, Charlotte (Melbourne Water Corporation)
Cassar, Susan (Melbourne Water Corporation)
Coventry, Kris (Melbourne Water Corporation)
Collignon, Peter (Canberra Hospital)
Allerberger, Franz (Austrian Agency for Health and Food Safety (AGES))
Rahube, Teddie O. (Botswana International University of Science and Technology)
Oliveira, Guilherme (Vale Institute of Technology. Sustainable Development)
Ivanov, Ivan (National Center of Infectious and Parasitic Diseases)
Vuthy, Yith (Institut Pasteur du Cambodge)
Sopheak, Thet (Institut Pasteur du Cambodge)
Yost, Christopher K. (University of Regina)
Ke, Changwen (Guangdong Provincial Center for Disease Control and Prevention)
Zheng, Huanying (Guangdong Provincial Center for Disease Control and Prevention)
Baisheng, Li (Guangdong Provincial Center for Disease Control and Prevention)
Jiao, Xiaoyang (Shantou University Medical College)
Donado-Godoy, Pilar (Corporacion Colombiana de Investigacion Agropecuaria (AGROSAVIA))
Coulibaly, Kalpy Julien (Institut Pasteur de Côte d'Ivoire)
Jergović, Matijana (Andrija Stampar Teaching Institute of Public Health)
Hrenovic, Jasna (University of Zagreb)
Karpíšková, Renáta (Veterinary Research Institute)
Villacis, Jose Eduardo (Instituto Nacional de Investigación en Salud Pública-INSPI (CRNRAM))
Legesse, Mengistu (Addis Ababa University)
Eguale, Tadesse (Addis Ababa University)
Heikinheimo, Annamari (University of Helsinki)
Malania, Lile (National Center for Disease Control and Public Health)
Nitsche, Andreas (Robert Koch Institute)
Brinkmann, Annika (Robert Koch Institute)
Saba, Courage Kosi Setsoafia (University for Development Studies)
Kocsis, Bela (Semmelweis University. Institute of Medical Microbiology)
Solymosi, Norbert (University of Veterinary Medicine)
Thorsteinsdottir, Thorunn R. (University of Iceland. Institute for Experimental Pathology)
Hatha, Abdulla Mohamed (Cochin University of Science and Technology)
Alebouyeh, Masoud (Shahid Beheshti University of Medical Sciences. Foodborne and Waterborne Diseases Research center)
Morris, Dearbhaile (National University of Ireland Galway)
Cormican, Martin (National University of Ireland Galway)
O'Connor, Louise (National University of Ireland Galway)
Moran-Gilad, Jacob (Ben Gurion University of the Negev and Ministry of Health. School of Public Health)
Alba, Patricia (Istituto Zooprofilattico Sperimentale del Lazio e della Toscana)
Battisti, Antonio (Istituto Zooprofilattico Sperimentale del Lazio e della Toscana)
Shakenova, Zeinegul (National Center of Expertise)
Kiiyukia, Ciira (Mount Kenya University)
Ng'eno, Eric (Kenya Medical Research Institute)
Raka, Lul (University of Prishtina "Hasan Prishtina" & National Institute of Public Health of Kosovo)
Avsejenko, Jeļena (Institute of Food Safety)
Bērziņš, Aivars (Institute of Food Safety)
Bartkevics, Vadims (Institute of Food Safety)
Penny, Christian (Luxembourg Institute of Science and Technology)
Rajandas, Heraa (Environmental Health Directorate)
Parimannan, Sivachandran (AIMST University (Malàisia). Centre of Excellence for Omics-Driven Computational Biodiscovery)
Haber, Malcolm Vella (Agriculture and Forestry University)
Pal, Pushkar (University of Otago)
Jeunen, Gert-Jan (University of Ibadan)
Gemmell, Neil (University of Ibadan)
Fashae, Kayode (VEAS)
Holmstad, Rune (Aga Khan University)
Hasan, Rumina (National Institute of Health)
Shakoor, Sadia (National Institute of Health)
Rojas, Maria Luz Zamudio (National Veterinary Research Institute)
Wasyl, Dariusz (Institute of Public Health of the Republic of Macedonia)
Bosevska, Golubinka (State Medical and Pharmaceutical University)
Kochubovski, Mihail (State Medical and Pharmaceutical University)
Radu, Cojocaru (Institut Pasteur de Dakar)
Gassama, Amy (Institute of Veterinary Medicine of Serbia)
Radosavljevic, Vladimir (Nanyang Technological University. Singapore Centre for Environmental Life Sciences Engineering (SCELSE))
Wuertz, Stefan (Nanyang Technological University Food Technology Centre (NAFTEC))
Zuniga-Montanez, Rogelio (Nanyang Technological University Food Technology Centre (NAFTEC))
Tay, Moon Y. F. (Public Health Authority of the Slovak Republic)
Gavačová, Dagmar (National Laboratory of Health. Environment and Food)
Pastuchova, Katarina (National Laboratory of Health. Environment and Food)
Truska, Peter (National Laboratory of Health. Environment and Food)
Trkov, Marija (Daspoort Waste Water Treatment Works)
Esterhuyse, Kerneels (University of the Witwatersrand)
Keddy, Karen (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Cerdà-Cuéllar, Marta (Medical Research Institute)
Pathirage, Sujatha (Swedish University of Agricultural Sciences)
Norrgren, Leif (The Sahlgrenska Academy at the University of Gothenburg)
Örn, Stefan (The Sahlgrenska Academy at the University of Gothenburg)
Larsson, D. G. Joakim (Ara Region Bern Ag)
Heijden, Tanja Van der (Kilimanjaro Clinical Research Institute)
Kumburu, Happiness Houka (National Public Health Laboratories)
Sanneh, Bakary (National Institute of Hygiene)
Bidjada, Pawou (Agence de Médecine Préventive)
Njanpop-Lafourcade, Berthe-Marie (Agence Médecine Préventive)
Nikiema-Pessinaba, Somtinda Christelle (Public Health Institution of Turkey)
Levent, Belkis (University of Washington)
Meschke, John Scott (Institute of Public Health in Ho Chi Minh City)
Beck, Nicola Koren (Institute of Public Health in Ho Chi Minh City)
Van, Chinh Dang (University of Zambia)
Phuc, Nguyen Do (University of Zambia)
Tran, Doan Minh Nguyen (University of Zambia)
Kwenda, Geoffrey (University of N'Djamena)
Tabo, Djim-adjim (Norwegian Institute of Public Health)
Wester, Astrid Louise (Universidad Católica del Maule)
Cuadros-Orellana, Sara (Universidad Católica del Maule. Centro de Biotecnología de los Recursos Naturales)
Amid, C. (European Molecular Biology Laboratory. European Bioinformatics Institute)
Cochrane, G. (European Molecular Biology Laboratory. European Bioinformatics Institute)
Sicheritz-Ponten, T. (AIMST University (Malàisia). Centre of Excellence for Omics-Driven Computational Biodiscovery)
Schmitt, H. (National Institute for Public Health and the Environment (RIVM))
Alvarez, J. R. M. (World Health Organization)
Aidara-Kane, A. (World Health Organization)
Pamp, S. J. (Technical University of Denmark. National Food Institute.)
Lund, O. (Technical University of Denmark. Department of Bio and Health Informatics.)
Hald, T. (Technical University of Denmark. National Food Institute.)
Woolhouse, M. (University of Edinburgh. Usher Institute)
Koopmans, M. P. (Erasmus Medical Center. Viroscience)
Vigre, H. (Technical University of Denmark. National Food Institute.)
Petersen, T. N. (Technical University of Denmark. National Food Institute.)
Aarestrup, Frank (Technical University of Denmark. National Food Institute.)

Data:	2019
Resum:	Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.
Ajuts:	European Commission 643476
Nota:	We are grateful to Hanne Nørgaard Nielsen, Christina Aaby Svendsen, Jacob Dyring Jensen, Birthe S. Rosenqvist Lund, Kate Vina Vibefeldt, Inge Marianne Hansen, Gunhild Larsen, Hanne Mordhorst, and Carsten Bidstrup for technical assistance. We also thank Jeffrey Edward Skiby for internal review. This study has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement no. 643476 (COMPARE), the World Health Organization, The Villum Foundation (VKR023052), and The Novo Nordisk Foundation (NNF16OC0021856: Global Surveillance of Antimicrobial Resistance).
Nota:	Altres ajuts: VF/VKR023052
Nota:	Altres ajuts: GSAR/NNF16OC0021856
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Africa ; Asia ; Bacteria ; Drug Resistance ; Epidemiological Monitoring ; Europe ; Genes ; Humans ; Metagenome ; Metagenomics ; Microbial Consortia ; North America ; Oceania ; Population Health ; Sewage ; Socioeconomic Factors ; South America
Publicat a:	Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 1124, ISSN 2041-1723

DOI: 10.1038/s41467-019-08853-3
PMID: 30850636

12 p, 3.9 MB

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