Unprecedented reorganization of holocentric chromosomes provides insights into the enigma of lepidopteran chromosome evolution
Hill, Jason (Uppsala University. Department of Medical Biochemistry and Microbiology)
Rastas, Pasi (University of Helsinki. Institute of Biotechnology)
Hornett, Emily A. (Liverpool School of Tropical Medicine. Department of Vector Biology)
Neethiraj, Ramprasad (Stockholm University. Department of Zoology. Population Genetics)
Clark, Nathan (University of Pittsburgh. Department of Computational and Systems Biology)
Morehouse, Nathan (University of Cincinnati. Department of Biological Sciences)
de la Paz Celorio-Mancera, Maria (Stockholm University. Department of Zoology. Population Genetics)
Carnicer i Cols, Jofre (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Dircksen, Heinrich (Stockholm University. Department of Zoology. Functional Morphology)
Meslin, Camille (INRA. Institute of Ecology and Environmental Sciences of Paris. Department of Sensory Ecology)
Keehnen, Naomi (Stockholm University. Department of Zoology. Population Genetics)
Pruisscher, Peter (Stockholm University. Department of Zoology. Population Genetics)
Sikkink, Kristin (University of Mississippi. Department of Biology)
Vives Ingla, Maria (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Vogel, Heiko (Max Planck Institute for Chemical Ecology. Department of Entomology)
Wiklund, Christer (Stockholm University. Department of Zoology. Population Genetics)
Woronik, Alyssa (New York University. Department of Biology. Center for Developmental Genetics)
Boggs, Carol L. (University of South Carolina. Department of Biological Sciences)
Nylin, Sören (Stockholm University. Department of Zoology. Population Genetics)
Wheat, Christopher W. (Stockholm University. Department of Zoology. Population Genetics)

Date:	2019
Abstract:	Chromosome evolution presents an enigma in the mega-diverse Lepidoptera. Most species exhibit constrained chromosome evolution with nearly identical haploid chromosome counts and chromosome-level gene collinearity among species more than 140 million years divergent. However, a few species possess radically inflated chromosomal counts due to extensive fission and fusion events. To address this enigma of constraint in the face of an exceptional ability to change, we investigated an unprecedented reorganization of the standard lepidopteran chromosome structure in the green-veined white butterfly (Pieris napi). We find that gene content in P. napi has been extensively rearranged in large collinear blocks, which until now have been masked by a haploid chromosome number close to the lepidopteran average. We observe that ancient chromosome ends have been maintained and collinear blocks are enriched for functionally related genes suggesting both a mechanism and a possible role for selection in determining the boundaries of these genome-wide rearrangements.
Grants:	Ministerio de Economía y Competitividad CGL2016-78093-R
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Chromosome evolution ; Chromosome numbers ; Chromosome structure ; Collinearity ; Gene content ; Lepidoptera ; Animals ; Bombyx ; Butterflies ; Chromosome Mapping ; Chromosomes, Insect ; Evolution, Molecular ; Female ; Genetic Linkage ; Genome Size ; Genome, Insect ; Male ; Phylogeny ; Ploidies ; Selection, Genetic
Published in:	Science advances, Vol. 5, Núm. 6 (Jun 2019) , p. eaau3648, ISSN 2375-2548

DOI: 10.1126/sciadv.aau3648
PMID: 31206013

13 p, 3.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > CREAF (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Articles > Research articles
Articles > Published articles