On the interpretation of the atmospheric mechanism transporting the environmental trigger of Kawasaki disease
Ballester, Joan (Barcelona Institute for Global Health (ISGlobal))
Borràs Aguadé, Sílvia (Barcelona Institute for Global Health (ISGlobal))
Curcoll Masanes, Roger (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals)
Navarro Gallinad, Albert (Barcelona Institute for Global Health (ISGlobal))
Pozdniakova, Sofya (Barcelona Institute for Global Health (ISGlobal))
Cañas, Lidia (Barcelona Institute for Global Health (ISGlobal))
Burns, Jane C. (University of California San Diego. Kawasaki Disease Research Center)
Rodó, Xavier (Institució Catalana de Recerca i Estudis Avançats)

Data:	2019
Resum:	Recent advances on the environmental determinants of Kawasaki Disease have pointed to the important role of the atmospheric transport of a still unknown agent potentially triggering the disease. The hypothesis arose from an innovative methodology combining expertise in climate dynamics, the analysis of ocean and atmosphere data, the use of dispersion models and the search for biological agents in air samples. The approach offered a new perspective to reveal the identity of the potential trigger, but at the same time, it increased the level of complexity, which could potentially lead to the misinterpretation of the mechanisms. Some years after it was originally formulated, we here provide a brief clarification on the approach and limits of the methodology in order to prevent an eventual misuse of our research ideas and theory, so that further research can better focus on the knowledge gaps that still remain open.
Ajuts:	European Commission 865564 European Commission 813545 European Commission 730004 European Commission 727852
Nota:	Unidad de excelencia María de Maeztu MdM-2015-0552
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Atmosphere ; Canada ; Climate ; Environment ; Environmental Monitoring ; Geography ; Humans ; Incidence ; Japan ; Mucocutaneous Lymph Node Syndrome ; New Zealand ; Precipitating Factors ; Risk Factors ; Seasons ; United States ; Wind
Publicat a:	PloS one, Vol. 14 issue 12 (Dec. 2019) , e0226402, ISSN 1932-6203

DOI: 10.1371/journal.pone.0226402
PMID: 31841545

7 p, 1.7 MB

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