Web of Science: 12 citas, Scopus: 13 citas, Google Scholar: citas
Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection
Aso, Ester (ALBA Laboratori de Llum de Sincrotró)
Martinsson, Isak (Wallenberg Neuroscience Center)
Appelhans, Dietmar (Leibniz Institute of Polymer Research Dresden)
Effenberg, Christiane (Leibniz Institute of Polymer Research Dresden)
Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró)
Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Gouras, Gunnar (Wallenberg Neuroscience Center)
Ferrer, Isidre (Hospital Universitari de Bellvitge)
Klementieva, Oxana (Wallenberg Neuroscience Center)

Fecha: 2019
Resumen: Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood-brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. Our data demonstrate that G4HisMal has significantly improved biocompatibility and ability to cross the blood-brain barrier in vivo. Therefore, we suggest that a maltose-histidine shell can be used to improve biocompatibility and ability to cross the blood-brain barrier of dendrimers. Moreover, G4HisMal demonstrated properties for synapse and memory protection when administered to Alzheimer disease transgenic mice. Therefore, G4HisMal can be considered as a promising drug candidate to prevent Alzheimer disease via synapse protection.
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Lengua: Anglès
Documento: article ; recerca ; publishedVersion
Materia: Dendrimers ; Histidine ; Maltose ; Biocompatibility ; Amyloid ; Synapses
Publicado en: Nanomedicine, Vol. 17 (April 2019) , p. 198-209, ISSN 1549-9642

DOI: 10.1016/j.nano.2019.01.010


12 p, 3.3 MB

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 Registro creado el 2020-06-03, última modificación el 2020-09-10



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