Ways forward for tolerance-inducing cellular therapies- An afactt perspective
ten Brinke, Anja (Sanquin Research. Department of Immunopathology)
Martinez-Llordella, Marc (King's College London. Department of Inflammation Biology)
Cools, Nathalie (University of Antwerp. Vaccine and Infectious Disease Institute)
Hilkens, Catharien M. U. (Newcastle University. Institute of Cellular Medicine)
Van Ham, S. Marieke (Sanquin Research. Department of Immunopathology)
Sawitzki, Birgit (Charité-Universitaetsmedizin Berlin)
Geissler, Edward K. (University Hospital Regensburg. Department of Surgery)
Lombardi, Giovanna (King's College London. MRC Centre for Transplantation)
Trzonkowski, Piotr (Medical University of Gdansk. Department of Clinical Immunology and Transplantology)
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol

Date:	2019
Abstract:	Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.
Grants:	European Commission 779316 European Commission 305147 European Commission 260687 Instituto de Salud Carlos III PI14/01175 Instituto de Salud Carlos III PI16/01737 Instituto de Salud Carlos III PI17/01521
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Tolerance ; Dendritic cells ; Regulatory T cells ; Autoimmunity ; Transplantation ; Cell therapy ; Clinic ; Immunomonitoring
Published in:	Frontiers in immunology, Vol. 10 (Feb. 2019) , art. 181, ISSN 1664-3224

DOI: 10.3389/fimmu.2019.00181
PMID: 30853957

20 p, 684.6 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles