Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014 : Incidence and comorbidities of antidepressant initiators
Forns, Joan (RTI Health Solutions. Epidemiology)
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark)
Reinders, Tammo (Leibniz Institute for Prevention Research and Epidemiology-BIPS)
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón)
Morros, Rosa (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Brandt, Lena (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital)
Cainzos-Achirica, Miguel (Epidemiology. RTI Health Solutions)
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark)
Schink, Tania (Leibniz Institute for Prevention Research and Epidemiology-BIPS)
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón)
Giner-Soriano, Maria (Institut Català de la Salut)
Hägg, David (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital)
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark)
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa)
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Les Laboratoires Servier)
Deltour, Nicolas (Pharmacoepidemiology Department. Les Laboratoires Servier)
Perez-Gutthann, S. (Epidemiology. RTI Health Solutions)
Pladevall-Vila, Manel (Epidemiology. RTI Health Solutions)
Reutfors, Johan (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital)

Date:	2019
Abstract:	Background: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009-2014 in Denmark, Germany, Spain, and Sweden. Methods: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine. Results: Citalopram was the most prescribed study antidepressant, followed by mirtazapine. Paroxetine and agomelatine were the least prescribed antidepressants. Mirtazapine was widely used among older antidepressant initiators with higher percentages of comorbidities at baseline, and fluoxetine was used among young patients. Citalopram and amitriptyline had the lowest percentage of multiple antidepressant use in the 12 months prior to the current treatment episode, while agomelatine, duloxetine, and venlafaxine had the highest percentage of multiple antidepressant use in the year prior to the current treatment episode. Limitations: The most important limitations are exposure information based on filled prescriptions, focus on antidepressant initiators only, lack of information on the indication, and heterogeneity of the type of data across data sources. Conclusions: Results of this study including 4. 8 million study antidepressant initiators of study antidepressants suggest that citalopram and mirtazapine are the most commonly prescribed antidepressants. Agomelatine and paroxetine were the least used antidepressants in the participating populations. Mirtazapine was the antidepressant most commonly prescribed among older antidepressant initiators with high percentage of comorbidities at baseline, whereas fluoxetine was commonly used among young patients.
Note:	Funding: the agomelatine post-authorisation study was funded by Les Laboratoires Servier under a contract granting independent publication rights to the research team. The present manuscript was funded by internal resources at each institution.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Journal of Affective Disorders, Vol. 249 (April 2019) , p. 242-252, ISSN 1573-2517

DOI: 10.1016/j.jad.2019.02.010
PMID: 30780117

11 p, 1.2 MB

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