Risk factors for graft failure after penetrating keratoplasty
Barraquer, Rafael I. (Rafael Ignasi) (Centre d'Oftalmologia Barraquer (Barcelona, Catalunya))
Pareja-Aricò, L. (Centre d'Oftalmologia Barraquer (Barcelona, Catalunya))
Gómez-Benlloch, Alba (Centre d'Oftalmologia Barraquer (Barcelona, Catalunya))
Michael, R. (Centre d'Oftalmologia Barraquer (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Data:	2019
Resum:	The objective of our study was to define principal risk factors for graft failure in patients who underwent penetrating keratoplasty (PK). Retrospective data obtained from a cohort of 895 penetrating keratoplasties performed between 2001 and 2006 were analysed. Recipient related factors, graft characteristics, and surgical technique were assessed in a univariate analysis and with a multivariate proportional hazard model to detect principal risk factors for definitive graft failure. Multivariate analysis showed clear significance for diagnosis and number of previous grafts and border line significance for the oldest donor age group. Patients with keratoconus had the best 10-year survival estimate (95%), followed by endothelial and stromal dystrophies (both 55%), infectious leukomas (49%), trauma (33%) and chemical burns (14%). Primary PK grafts had a survival rate of 81%, second grafts of 33% and third or more grafts of 16%. Overall 10-year survival estimate based on univariate analysis was found to be 65%. In conclusion, we found that primary diagnosis and previous graft failures in the recipient are the most important risk factors of graft failure after a PK.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cornea ; Graft failure ; Multivariate analysis ; Penetrating keratoplasty ; Risk factors
Publicat a:	Medicine, Vol. 98 Núm. 17 (april 2019) , p. e15274, ISSN 1536-5964

DOI: 10.1097/MD.0000000000015274
PMID: 31027083

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