Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
Pretus, Clara (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Marcos-Vidal, Luís. (Universidad Carlos III de Madrid. Departamento de Bioingeniería e Ingeniería Aeroespacial)
Martínez-García, Magdalena (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Picado, Marisol (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Ramos-Quiroga, Josep Antoni (Hospital Universitari Vall d'Hebron)
Richarte, Vanesa (Hospital Universitari Vall d'Hebron)
Castellanos, Francisco X. (Nathan Kline Institute for Psychiatric Research)
Sepulcre, Jorge. (Harvard Medical School)
Desco, Manuel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Vilarroya Oliver, Óscar (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Carmona Cañabate, Susana (Universidad Carlos III de Madrid. Departamento de Bioingeniería e Ingeniería Aeroespacial)

Date:	2019
Abstract:	Neuroimaging studies indicate that children with attention-deficit/hyperactivity disorder (ADHD) present alterations in several functional networks of the sensation-to-cognition spectrum. These alterations include functional overconnectivity within sensory regions and underconnectivity between sensory regions and neural hubs supporting higher order cognitive functions. Today, it is unknown whether this same pattern of alterations persists in adult patients with ADHD who had never been medicated for their condition. The aim of the present study was to assess whether medication-naïve adults with ADHD presented alterations in functional networks of the sensation-to-cognition spectrum. Thirty-one medication-naïve adults with ADHD and twenty-two healthy adults underwent resting-state functional magnetic resonance imaging (rs-fMRI). Stepwise functional connectivity (SFC) was used to characterize the pattern of functional connectivity between sensory seed regions and the rest of the brain at direct, short, intermediate, and long functional connectivity distances, thus covering the continuum from the sensory input to the neural hubs supporting higher order cognitive functions. As compared to controls, adults with ADHD presented increased SFC degree within primary sensory regions and decreased SFC degree between sensory seeds and higher order integration nodes. In addition, they exhibited decreased connectivity degree between sensory seeds and regions of the default-mode network. Consistently, the higher the score in clinical severity scales the lower connectivity degree between seed regions and the default mode network.
Grants:	Ministerio de Economía y Competitividad SAF2012-32362 Instituto de Salud Carlos III CP16-00096 Instituto de Salud Carlos III PI17-00064 Instituto de Salud Carlos III FI18-00255
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	ADHD, adult ADHD ; Default mode network ; Resting-state fMRI ; Stepwise functional ; Connectivity
Published in:	Human brain mapping, Vol. 40 Núm. 16 (january 2019) , p. 4645-4656, ISSN 1097-0193

DOI: 10.1002/hbm.24727
PMID: 31322305

12 p, 4.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles