A hexa-quinoline based C 3-symmetric chemosensor for dual sensing of zinc(ii) and PPi in an aqueous medium via chelation induced "oFF-ON-OFF" emission
Sinha, Sanghamitra (Indian Association for the Cultivation of Science)
Chowdhury, Bijit (Indian Association for the Cultivation of Science)
Adarsh, Nayarassery N. (Institut Català de Nanociència i Nanotecnologia)
Ghosh, Pradyut (Indian Association for the Cultivation of Science)

Data:	2018
Resum:	A quinoline-based C-symmetric fluorescent probe (1), N,N',N''-((2,4,6-trimethylbenzene-1,3,5-triyl)tris(methylene))tris(1-(quinolin-2-yl)-N-(quinolin-2-ylmethyl)methanamine), has been developed which can selectively detect Zn without the interference of Cdvia significant enhancement in emission intensity (fluorescence "turn-ON") associated with distinct fluorescence colour changes and very low detection limits (35. 60 × 10 M in acetonitrile and 29. 45 × 10 M in 50% aqueous buffer (10 mM HEPES, pH = 7. 4) acetonitrile media). Importantly, this sensor is operative with a broad pH window (pH 4-10). The sensing phenomenon has been duly studied through UV-vis, steady-state, and time-resolved fluorescence spectroscopic methods indicating 1:3 stoichiometric binding between 1 and Zn which is further corroborated by H NMR studies. Density functional theoretical (DFT) calculations provide the optimized molecular geometry and properties of the zinc complex, 1[Zn(ClO)] , which is proposed to be formed in acetonitrile. The results are in line with the solution-state experimental findings. The single crystal X-ray study provides the solid state structure of the trinuclear Zn complex showing solubility in an aqueous buffer (10 mM HEPES, pH = 7. 4). Finally, the resulting trinuclear Zn complex has been utilized as a fluorescence "turn-OFF" sensor for the selective detection of pyrophosphate in a 70% aqueous buffer (10 mM HEPES, pH = 7. 4) acetonitrile solvent with a nanomolar detection limit (45. 37 × 10 M).
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Density functionals ; Low detection limit ; Molecular geometries ; Nanomolar detection limits ; Solid-state structures ; Spectroscopic method ; Stoichiometric binding ; Time-resolved fluorescence
Publicat a:	Dalton transactions, Vol. 47, Issue 19 (May 2018) , p. 6819-6830, ISSN 1477-9234

DOI: 10.1039/c8dt00611c
PMID: 29725677

Postprint 30 p, 970.1 KB

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