Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
Gersner, Roman (Harvard Medical School)
Paredes, Carmen (Harvard Medical School)
Hameed, Mustafa Q. (Harvard Medical School)
Dhamne, Sameer C. (Harvard Medical School)
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Rotenberg, Alexander (Beth Israel Deaconess Cancer Center (Boston, Estats Units d'Amèrica))

Date:	2020
Abstract:	Automated anesthesia systems that continuously monitor cortical excitability (CE) changes to govern drug infusion rates, are desirable. Paired-pulse transcranial magnetic stimulation (ppTMS), with electromyography (EMG), provides noninvasive CE measures. We tested whether, and with what temporal resolution, ppTMS-EMG detects dose-dependent CE in rats anesthetized with continuous intravenous propofol. Motor-evoked potentials (MEPs) were recorded every 20 seconds as either propofol bolus or change in infusion rate was applied. ppTMS-derived measures varied in direct proportion to propofol dose with subminute temporal resolution. We conclude that ppTMS-EMG enables real-time markers of target engagement by anesthetics that may be incorporated into an automated device.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Annals of clinical and translational neurology, Vol. 7 Num. 3 (2020) , p. 384-389, ISSN 2328-9503

DOI: 10.1002/acn3.50981
PMID: 32061019

6 p, 1.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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