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| Home > Articles > Published articles > Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep |
(Institut de Ciències Fotòniques) (Institut de Ciències Fotòniques) (Institut de Ciències Fotòniques) (Institut d'Investigació Biomèdica Sant Pau) (Centre de Recerca Matemàtica) (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) (Institució Catalana de Recerca i Estudis Avançats)| Date: | 2018 |
| Abstract: | Obstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may improve our knowledge of these consequences and then allow for the development of preventive strategies. Our aim was to characterize the typical microvascular, cortical cerebral blood flow (CBF) changes in an OSA population during an apneic event. Sixteen patients (age , 75% male) with a high risk of severe OSA were measured with a polysomnography device and with diffuse correlation spectroscopy (DCS) during one night of sleep with 1365 obstructive apneic events detected. All patients were later confirmed to suffer from severe OSA syndrome with a mean of apneas and hypopneas per hour. DCS has been shown to be able to characterize the microvascular CBF response to each event with a sufficient contrast-to-noise ratio to reveal its dynamics. It has also revealed that an apnea causes a peak increase of microvascular CBF () at the end of the event followed by a drop () similar to what was observed in macrovascular CBF velocity of the middle cerebral artery. This study paves the way for the utilization of DCS for further studies on these populations. |
| Grants: | Ministerio de Economía y Competitividad DPI2015-64358-C2-1-R Ministerio de Economía y Competitividad DPI2015-68820-R Ministerio de Economía y Competitividad FIS2015-71851-P Instituto de Salud Carlos III DTS16-00087 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1380 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1307 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1569 |
| Note: | Altres ajuts: This work was funded by the "Severo Ochoa" Programme for Centres of Excellence in R&D (Grant No. SEV-2015-0522), the Obra Social "la Caixa" Foundation (Grant Nos. LlumMedBcn, Programa de Matemàtica Col·laborativa), LASERLABEUROPE IV (Grant No. EU-H2020 654148), Marie Curie initial training network (Grant No. OILTEBIA 317526), Societat Catalana de Pneumologia (SOCAP), and Sociedad Española de Neumología y Cirugía Torácica (SEPAR) ; Ministerio de Economía y Competitividad PHOTODEMENTIA |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Sleep disorder breathing ; Cerebral blood flow ; Brain perfusion ; Diffuse correlation spectroscopy |
| Published in: | Neurophotonics, Vol. 5 (november 2018) , ISSN 2329-4248 |
