Childhood maltreatment and risk for suicide attempts in major depression : a sex-specific approach
Goldberg, Ximena (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Serra-Blasco, Maria (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Vicent-Gil, Muriel (Institut d'Investigació Biomèdica Sant Pau)
Aguilar, Eva (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ros, Laura (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Arias, Barbara (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)
Courtet, Philippe (Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Hopital Lapeyronie, INSERM Unit 1061, University of Montpellier)
Palao, Diego (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Cardoner, N. (Narcís) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Universitat Autònoma de Barcelona

Date:	2019
Abstract:	Background : Childhood maltreatment increases the risk of suicide attempts in the general population, possibly having similar effects among patients with major depressive disorder (MDD). The few studies that have addressed this association have been restricted to specific populations (e. g. treatment-resistant depression, personality disorders) and have rarely taken sex into account. Objective : To examine the impact of childhood maltreatment on suicide attempts among MDD patients above and beyond other risk factors and potential confounders, while considering potential sex-specific effects. Methods : The study assessed 165 patients with a principal diagnosis of MDD. Neurological alterations, psychiatric comorbidities, and drug abuse were reasons for exclusion. Logistic regressions using the whole sample, and divided by sex, were run to test the association between childhood maltreatment and history of suicide attempts, controlling for symptom severity, comorbidities, and treatment-resistant depression. Results : There was a significant and clinically relevant association between childhood maltreatment and history of suicide attempts in the total sample. Patients with childhood maltreatment were 3. 01 times more likely to present a history of suicide attempts than patients without childhood maltreatment. A family history of psychiatric disorders also contributed to the variance of attempted suicide, but its interaction with childhood maltreatment was not statistically significant. When testing the model separately, the effect of childhood maltreatment on suicide attempts remained for females, whereas for males, age of MDD onset and Childhood Trauma Questionnaire minimization-denial scale were predictive variables. Conclusions : Childhood maltreatment is a clear predictor of suicidal behaviour among MDD patients, and this effect remains significant after controlling for potential confounders. Also, the sex of patients emerges as a relevant factor that may model the mechanisms underlying the prediction of suicide attempts. Since suicide is the main cause of premature death among MDD patients, interventions targeting childhood maltreatment should be included in preventive and clinical strategies.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca SLT002/16/00254 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014 SGR 1636 Ministerio de Economía y Competitividad PI160998
Note:	Altres ajuts: This work was supported partly by a non-competitive grant from the Health Department of the Generalitat de Catalunya (PREDI-NU project, European Alliance Against Depression, 2016); Fondo Europeo de Desarrollo Regional, Unión Europea, Una manera de hacer Europa, CIBERSAM, Secretaria d'Universitats.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Childhood maltreatment ; Depression ; Suicide attempts ; Risk factors ; Sex differences ; 童年虐待 ; 抑郁 ; 自杀企图 ; 风险因素 ; 性别差异 ; • Childhood maltreatment significantly increases the risk of suicide attempts in MDD patients, above and beyond previously proposed factors.• This association is particularly evident among female MDD patients.• The underlying mechanisms in male patients may be dependent on further biopsychological factors.• MDD patients should be screened for childhood maltreatment as a strategy to prevent suicide attempts in adulthood
Published in:	European Journal of Psychotraumatology, Vol. 10 (may 2019) , ISSN 2000-8066

DOI: 10.1080/20008198.2019.1603557
PMID: 31105902

12 p, 1.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles