Vibrating Tail, Digging, Body/Face Interaction, and Lack of Barbering : Sex-Dependent Behavioral Signatures of Social Dysfunction in 3xTg-AD Mice as Compared to Mice with Normal Aging
Torres-Lista, Virginia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2019
Abstract:	Modeling of Alzheimer's disease (AD), classically focused on the subject-environment interaction, foresees current social neuroscience efforts as improving the predictive validity of new strategies. Here we studied social functioning among congeners in 13-14-month-old mice with normal aging in naturalistic and experimental conditions and depicted behavioral signatures of dysfunction in age-matched 3xTg-AD mice. The most sensitive variables were vibrating tail, digging, body/face and self-grooming, that can be easily used in housing routines and the assessment of strategies. Sex-specific signatures (vibrating tail, digging, and grooming) defined female 3xTg-AD mice ethogram. All animals sleep huddled while barbering was only found in females with normal aging.
Grants:	Instituto de Salud Carlos III AES-PI10/00283 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1468 European Commission 737390
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Barbering ; Behavioral and psychological symptoms of dementia ; Dalila effect ; Digging ; Ethogram markers ; Monitoring ; Sleeping behavior ; Social behavior ; Social Interaction Test ; Tube-dominance test
Published in:	Journal of Alzheimer's disease, Vol. 69 (june 2019) , p. 969-977, ISSN 1875-8908

DOI: 10.3233/JAD-190253
PMID: 31156176

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles