Sodium-glucose cotransporter inhibitors : beyond glycaemic control
Vergara, Ander (Hospital Universitari Vall d'Hebron)
Jacobs-Cachá, Conxita (Vall d'Hebron Institut de Recerca (VHIR))
Soler, María José (Vall d'Hebron Institut de Recerca (VHIR))
Universitat Autònoma de Barcelona
Hospital Universitari Vall d'Hebron

Data:	2019
Resum:	Diabetes increases the risk of adverse cardiovascular and renal events. Recently, sodium-glucose co-transporter 2 (SGLT2) inhibitors have been demonstrated to reduce cardiovascular complications and slow diabetic kidney disease progression in patients with type 2 diabetes. The glycaemic control exerted by these drugs is not greater than the one achieved with other classical glucose-lowering medications such as sulphonylureas. For that reason, plausible renoprotective mechanisms independent from glycaemic control have been proposed such as blood pressure control, body weight loss, intraglomerular pressure reduction and a decrease in urinary proximal tubular injury biomarkers. Interestingly, the hypothesis that SGLT2 inhibitors have a direct renoprotective effect has been addressed in diabetic and non-diabetic models. In this editorial, we update the different postulated mechanisms involved in the cardiorenal protection afforded by SGLT2 inhibition in chronic kidney disease.
Ajuts:	Instituto de Salud Carlos III PI17/00257
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	Chronic kidney disease ; Diabetic nephropathy ; SGLT2 ; Type 2 diabetes
Publicat a:	Clinical Kidney Journal, Vol. 12 (march 2019) , p. 322-325, ISSN 2048-8513

DOI: 10.1093/ckj/sfz019
PMID: 31198226

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