Validation of a score to identify inpatients at risk of a drug-related problem during a 4-year period
Ferrández, Olivia (Hospital del Mar (Barcelona, Catalunya))
Grau, Santiago (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Urbina, O. (Hospital del Mar (Barcelona, Catalunya))
Mojal, S. (Institut Hospital del Mar d'Investigacions Mèdiques)
Riu i Camps, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Salas, Esther (Hospital del Mar (Barcelona, Catalunya))

Data:	2018
Resum:	Drug-related problems (DRP) produce high morbidity and mortality. It is therefore essential to identify patients at higher risk of these events. This study aimed to validate a DRP risk score in a large number of inpatients. Validation of a previously designed score to identify inpatients at risk of experiencing at least one DRP in a tertiary university hospital from 2010 to 2013. DRP were detected by a pharmacy warning system integrated in the electronic medical record. The score included the following variables associated with a higher risk of DRP: prescription of a higher number of drugs, greater comorbidity, advanced age, specific ATC groups and certain major diagnostic categories. The study included a total of 52,987 admissions; of these, at least one DRP occurred in 14. 9%. After validation of the score (period range, 2010-2013: 0. 746-0. 764), the area under the curve (AUC) was 0. 751 (95% CI: 0. 745-0. 756). This value is higher than those reported in other studies describing validation of risk scores. The score showed good capacity to identify those patients at higher risk of DRP in a much larger sample of inpatients than previously described in the literature. This tool allows optimization of drug therapy monitoring in admitted patients.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Drug-related problems ; Computerized medical record system ; Computerized physician order entry ; Risk score ; Patient safety
Publicat a:	Saudi Pharmaceutical Journal : SPJ, Vol. 26 (february 2018) , p. 703-708, ISSN 2213-7475

DOI: 10.1016/j.jsps.2018.02.020
PMID: 29991914

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