Second-Generation Insulin Analogues - a Review of Recent Real-World Data and Forthcoming Head-to-Head Comparisons
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Hramiak, Irene (Lawson Research Institute, London, ON, Canada)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	Insulin analogues play a key role in the effective management of type 2 diabetes. However, there are several behavioural barriers to appropriate early initiation of insulin therapy, despite compelling evidence supporting the benefits of this strategy in those patients for whom oral anti-diabetes agents provide insufficient control. The development of second-generation insulin analogues (insulin glargine 300 U/mL and insulin degludec) has provided physicians with agents that can provide comparable glycaemic control to first-generation insulin, but with a reduced risk of hypoglycaemia and modes of action suited to once-daily regimens. These characteristics may help overcome patient and physician concerns about early insulin use in disease management. To date, there have been no head-to-head comparisons of second-generation insulins: here we consider recent real-world evidence and the forthcoming direct comparison in the BRIGHT randomised controlled study, as presented at the recent 11 th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD) 2018.
Note:	Altres ajuts: Editorial assistance was provided by Touch Medical Media and was funded by Sanofi.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Second-generation ; Insulin glargine 300 ; Once-daily insulin ; Hypoglycaemia ; Type 2 diabetes
Published in:	European Endocrinology, Vol. 14 (may 2018) , p. 2-9, ISSN 1758-3780

DOI: 10.17925/EE.2018.14supp1.2
PMID: 30034546

10 p, 2.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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