Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan
Franke, Barbara (Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands)
Michelini, Giorgia (King's College London, Institute of Psychiatry, Psychology and Neuroscience)
Asherson, Philip (King's College London, Institute of Psychiatry, Psychology and Neuroscience)
Banaschewski, Tobias (Central Institute of Mental Health (Manheim, Alemanya))
Bilbow, Andrea (ADHD-Europe, Brussels, Belgium)
Buitelaar, Jan (Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, The Netherlands)
Cormand, Bru (Institut de Recerca Sant Joan de Déu)
Faraone, Stephen V. (K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway)
Ginsberg, Ylva (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience)
Haavik, Jan (Haukeland University Hospital (Bergen, Noruega))
Kuntsi, Jonna (King's College London, Institute of Psychiatry, Psychology and Neuroscience)
Larsson, Henrik (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience)
Lesch, Klaus-Peter (Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands)
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Réthelyi, János M. (MTA-SE NAP-B Molecular Psychiatry Research Group, Hungarian Academy of Sciences, Budapest, Hungary)
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Reif, Andreas (University Hospital of Frankfurt (Alemanya))

Fecha:	2018
Resumen:	Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but persists into adulthood. Both in childhood and adulthood, ADHD is characterised by substantial comorbidity including substance use, depression, anxiety, and accidents. However, course and symptoms of the disorder and the comorbidities may fluctuate and change over time, and even age of onset in childhood has recently been questioned. Available evidence to date is poor and largely inconsistent with regard to the predictors of persistence versus remittance. Likewise, the development of comorbid disorders cannot be foreseen early on, hampering preventive measures. These facts call for a lifespan perspective on ADHD from childhood to old age. In this selective review, we summarise current knowledge of the long-term course of ADHD, with an emphasis on clinical symptom and cognitive trajectories, treatment effects over the lifespan, and the development of comorbidities. Also, we summarise current knowledge and important unresolved issues on biological factors underlying different ADHD trajectories. We conclude that a severe lack of knowledge on lifespan aspects in ADHD still exists for nearly every aspect reviewed. We encourage large-scale research efforts to overcome those knowledge gaps through appropriately granular longitudinal studies.
Ayudas:	European Commission 643051 European Commission 667302 Ministerio de Economía y Competitividad SAF2015-68341-R Ministerio de Economía y Competitividad CP09-00119 Ministerio de Economía y Competitividad CPII15-00023 Ministerio de Economía y Competitividad PI14-01700 Ministerio de Economía y Competitividad PI17-00289 Ministerio de Economía y Competitividad PI12-01139 Ministerio de Economía y Competitividad PI15-01789 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR1357 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR932
Nota:	Altres ajuts: This study has been produced by members of the "International Multicentre persistent ADHD Collaboration" (IMpACT; www.impactadhdgenomics.com) and the ECNP for the Research Network "ADHD across the Lifespan" (https://www.ecnp.eu/research-innovation/ECNP-networks/List-ECNP-Networks/ADHD.aspx). IMpACT unites major research centres working on the genetics of ADHD persistence across the lifespan and has participants in the Netherlands, Germany, Spain, Norway, the United Kingdom, the United States, Brazil, and Sweden. Principal investigators of IMpACT are: Barbara Franke (chair), Andreas Reif (co-chair), Stephen V. Faraone, Jan Haavik, Bru Cormand, J. Antoni Ramos-Quiroga, Philip Asherson, Klaus-Peter Lesch, Jonna Kuntsi, Claiton H.D. Bau, Jan K. Buitelaar, Stefan Johansson, Henrik Larsson, Alysa Doyle, and Eugenio H. Grevet. Their work is supported by European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 602805 (AGGRESSOTYPE), 603016 (MATRICS), 278948 (TACTICS), 602450 (IMAGEMEND) and from the European Community's Horizon 2020 Programme (H2020/2014 - 2020). Barbara Franke also receives support from the Netherlands Organization for Scientific Research (NWO), i.e. the Vici Innovation Program (grant 016-130-669). Andreas Reif is supported by the BMBF (BipoLife) and the DFG (CRC 1193, C07 and Z03). János M. Réthelyi is supported by the Hungarian Brain Research Program (Grant NAP-B KTIA_NAP_13-2014-0011). Giorgia Michelini was supported by a 1 + 3 PhD studentship awarded by the MRC Social, Genetic & Developmental Psychiatry Centre, King's College London (G9817803). Bru Cormand received support from the Spanish "Ministerio de Economía y Competitividad" and AGAUR, "Generalitat de Catalunya". J. Antoni Ramos-Quiroga received support by Instituto de Salud Carlos III, and cofinanced by Agència de Gestió d'Ajuts Universitaris i de Recerca-AGAUR, Generalitat de Catalunya, Departament de Salut, Generalitat de Catalunya, Spain. Marta Ribases received support from the Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad, Spain and from a NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation. The funders had no further role in the writing of this manuscript and in the decision to submit it for publication.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Developmental trajectory ; Treatment ; Comorbidity ; Cognitive impairment ; Genetics ; Adult-onset ADHD
Publicado en:	European neuropsychopharmacology, Vol. 28 (october 2018) , p. 1059-1088, ISSN 1873-7862

DOI: 10.1016/j.euroneuro.2018.08.001
PMID: 30195575

30 p, 2.0 MB

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